The tumor suppressor p53 is lost or mutated in about half of all human cancers, and in those
tumors in which it is wild-type, mechanisms exist to prevent its activation. p53 loss not only …

Nitric oxide (NO) generated by the inducible isoform of nitric oxide synthase (iNOS) is
involved in complex immunomodulatory and antitumoral mechanisms and has been …

In transitional cell carcinoma, the most common form of bladder cancer, overexpression of
the matrix metalloproteinases MMP-2 and MMP-9 offers prognostic value as markers of …

Aneurysmal bone cyst (ABC) is an aggressive, pediatric bone tumor characterized by
extensive destruction of the surrounding bone. Although first described over 60 years ago …

Melanoma is a highly metastatic cancer, and there are no current therapeutic modalities to
treat this deadly malignant disease once it has metastasized. Melanoma cancers exhibit B …

The traditional Chinese medicinal mushroom, Ganoderma lucidum, has been used in Asia
for several thousand years for the prevention and treatment of a variety of diseases …

Premalignant cells acquire a series of genetic and epigenetic changes that are responsible
for cell proliferation in the absence of growth factors. It is not yet defined how the initial steps …

The designed compounds, 4a–p, were synthesized using a simple and smooth method with
an asymmetric 1, 3-dipolar reaction as the key step. The chemical structures for all …

Articular adipose tissue is a ubiquitous component of human joints, and adiponectin is a
protein hormone secreted predominantly by differentiated adipocytes and involved in energy …

The transcription factors p53 and NFκB determine cellular fate and are involved in the
pathogenesis of most–if not all–cancers. The crosstalk between these transcription factors …