Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

Voltage‐gated sodium channels initiate action potentials in nerve, muscle and other
excitable cells. The sodium current that initiates the nerve action potential was discovered by …

Nociception is essential for survival whereas pathological pain is maladaptive and often
unresponsive to pharmacotherapy. Voltage-gated sodium channels, Nav1. 1–Nav1. 9, are …

Nine voltage-gated sodium channels are expressed in complex patterns in mammalian
nerve and muscle. Three channels, Nav1. 7, Nav1. 8, and Nav1. 9, are expressed selectively …

Acute, inflammatory, and neuropathic pain can all be attenuated or abolished by local
treatment with sodium channel blockers such as lidocaine. The peripheral input that drives …

We used a mouse with deletion of exons 4, 5, and 6 of the SCN11A (sodium channel,
voltage-gated, type XI, α) gene that encodes the voltage-gated sodium channel Nav1. 9 to …

Diabetic neuropathy is a common form of peripheral neuropathy, yet the mechanisms
responsible for pain in this disease are poorly understood. Alterations in the expression and …

Mechanical allodynia (other pain) is a painful sensation caused by innocuous stimuli like
light touch. Unlike inflammatory hyperalgesia that has a protective role, allodynia has no …

Pain is associated with several conditions, such as inflammation, that result from altered
peripheral nerve properties. Electroacupuncture (EA) is a common Chinese clinical medical …

Genetic ablation of the fibroblast growth factor (Fgf) 14 gene in mice or a missense mutation
in Fgf14 in humans causes ataxia and cognitive deficits. These phenotypes suggest that the …