Research efforts during the past decades have provided intriguing evidence suggesting that
stressful experiences during pregnancy exert long-term consequences on the future mental …

Major depressive disorder (MDD) is a multifactorial and polygenic disorder, where multiple
and partially overlapping sets of susceptibility genes interact each other and with the …

Although beta-endorphinergic neurons in the hypothalamic arcuate nucleus (ARC)
synthesize beta-endorphin (β-EP) to alleviate nociceptive behaviors, the underlying …

The gestational state is a period of particular vulnerability to diseases that affect maternal
and fetal health. Stress during gestation may represent a powerful influence on maternal …

Stress is an adaptive response to environment aversive stimuli and a common life
experience of one's daily life. Chronic or excessive stress especially that happened in early …

Background Chronic stress is considered to be one of many causes of human preterm birth
(PTB), but no direct evidence has yet been provided. Here we show in rats that stress across …

The brain is the central organ of the body's response to and perception of stress. Both the
juvenile and the adult brain show a significant capacity for lasting physiological, structural …

The developmental processes that establish the synaptic architecture of the brain while
retaining capacity for activity-dependent remodeling, are complex and involve a combination …

Preterm birth is a universal health problem that is one of the largest unmet medical needs
contributing to the global burden of disease. Adding to its complexity is that there are no …

Stress, a common if unpredictable life event, can have pronounced effects on physiology
and behavior. Individuals show wide variation in stress susceptibility and resilience, which …