S100A9/S100A8 (calprotectin), a member of the S100 protein family, has been shown to
play a pivotal role in innate immunity activation. Calprotectin plays a critical role in the …

Abstract S100A8 and S100A9 are novel members of the group of damage–associated
molecular pattern molecules (DAMP) which are early amplifiers of innate immune responses …

Damage-associated molecular pattern (DAMP) molecules have been introduced as
important proinflammatory factors of innate immunity. One example known for many years to …

Objective To conduct a prospective cohort study using anakinra, a recombinant IL‐1
receptor antagonist (IL‐1Ra), as first‐line therapy in patients with new‐onset systemic …

Abstract MRP14 (S100A9) is the major calcium-binding protein of neutrophils and
monocytes. Targeted gene disruption reveals an essential role of this S100 protein for …

Abstract S100A8 and S100A9, two Ca 2+-binding proteins of the S100 family, are secreted
as a heterodimeric complex (S100A8/A9) from neutrophils and monocytes/macrophages …

Abstract Myeloid-related protein 8 (MRP8) and MRP14, S100 proteins secreted by activated
phagocytes, bind specifically to endothelial cells. The endothelial response to …

Rheumatic diseases are characterized by sterile inflammation that causes severe long-term
damage to various organ systems. A growing body of evidence supports a pivotal role for the …

The EF-hand homolog family of S100 proteins comprises the largest group of calcium-
binding proteins. Within this S100 family, the phagocyte-specific calcium-binding proteins …

Alarmins (also known as danger signals) are endogenous molecules that are released to
the extracellular milieu after infection or tissue damage. Extracellular alarmins interact with …