Tendon injuries are common and present a clinical challenge to orthopedic surgery mainly
because these injuries often respond poorly to treatment and require prolonged …

Tendon is a crucial component of the musculoskeletal system. Tendons connect muscle to
bone and transmit forces to produce motion. Chronic and acute tendon injuries are very …

Injuries to the musculoskeletal system are common, debilitating and expensive. In many
cases, healing is imperfect, which leads to chronic impairment. Gene transfer might improve …

Tendon formation and repair rely on specific combinations of transcription factors, growth
factors, and mechanical parameters that regulate the production and spatial organization of …

The last decade has seen significant developments in cell therapies, based on permanently
differentiated, reprogrammed or engineered stem cells, for tendon injuries and degenerative …

Tendons and ligaments are extracellular matrix (ECM)-rich structures that interconnect
muscles and bones. Recent work has shown how tendon fibroblasts (tenocytes) interact with …

Tenomodulin (Tnmd) is a type II transmembrane glycoprotein predominantly expressed in
tendons and ligaments. We found that scleraxis (Scx), a member of the Twist-family of basic …

Although the link between altered stem cell properties and tissue aging has been
recognized, the molecular and cellular processes of tendon aging have not been elucidated …

Abstract Background Mesenchymal stem cells (MSCs) are multipotent stem cells that can be
isolated and expanded from many tissues, and are being investigated for use in cell …

Abstract The transcription factor Mohawk (Mkx) is expressed in developing tendons and is
an important regulator of tenogenic differentiation. However, the exact roles of Mkx in …