[HTML][HTML] May the force be with you (or not): The immune system under microgravity

M ElGindi, J Sapudom, IH Ibrahim, M Al-Sayegh… - Cells, 2021 - mdpi.com
All terrestrial organisms have evolved and adapted to thrive under Earth's gravitational force.
Due to the increase of crewed space flights in recent years, it is vital to understand how the …

Biomimetic tumor microenvironments based on collagen matrices

J Sapudom, T Pompe - Biomaterials science, 2018 - pubs.rsc.org
The extracellular matrix (ECM) establishes the basis for the cell's microenvironment
providing structural and mechanical support to cells and tissues, and regulating multiple cell …

[HTML][HTML] 3D in vitro M2 macrophage model to mimic modulation of tissue repair

J Sapudom, S Karaman, WKE Mohamed… - npj Regenerative …, 2021 - nature.com
Distinct anti-inflammatory macrophage (M2) subtypes, namely M2a and M2c, are reported to
modulate the tissue repair process tightly and chronologically by modulating fibroblast …

[HTML][HTML] Collagen fibril density modulates macrophage activation and cellular functions during tissue repair

J Sapudom, WKE Mohamed, A Garcia-Sabaté… - Bioengineering, 2020 - mdpi.com
Monocytes circulate in the bloodstream, extravasate into the tissue and differentiate into
specific macrophage phenotypes to fulfill the immunological needs of tissues. During the …

The blood–brain barrier and beyond: Nano-based neuropharmacology and the role of extracellular matrix

P Henrich-Noack, D Nikitovic, M Neagu… - … , Biology and Medicine, 2019 - Elsevier
Restrained drug delivery due to the blood–brain barrier (BBB) considerably limits options for
the treatment of brain pathologies. The utilization of nanoparticulate (NP) carriers has been …

Dendritic cell immune potency on 2D and in 3D collagen matrices

J Sapudom, A Alatoom, WKE Mohamed… - Biomaterials …, 2020 - pubs.rsc.org
Dendritic cells (DCs) are antigen-presenting cells capable of either activating the immune
response or inducing and maintaining immune tolerance. Understanding how biophysical …

[HTML][HTML] Fibroblast differentiation and matrix remodeling impaired under simulated microgravity in 3D cell culture model

J Sapudom, M ElGindi, M Arnoux, N Drou… - International journal of …, 2021 - mdpi.com
Exposure to microgravity affects astronauts' health in adverse ways. However, less is known
about the extent to which fibroblast differentiation during the wound healing process is …

A Fully 3D Interconnected Graphene–Carbon Nanotube Web Allows the Study of Glioma Infiltration in Bioengineered 3D Cortex‐Like Networks

M Xiao, X Li, Q Song, Q Zhang, M Lazzarino… - Advanced …, 2018 - Wiley Online Library
Currently available 3D assemblies based on carbon nanotubes (CNTs) lag far behind their
2D CNT‐based bricks and require major improvements for biological applications. By using …

Long-time viscoelasticity of multicellular surfaces caused by collective cell migration–multi-scale modeling considerations

I Pajic-Lijakovic, M Milivojevic - Seminars in Cell & Developmental Biology, 2019 - Elsevier
Long-time viscoelasticity of multicellular surfaces caused by collective cell migration
depends on:(1) the volume fraction and configuration of migrating cells and the rate of its …

DefocusTracker: A modular toolbox for defocusing-based, single-camera, 3D particle tracking

R Barnkob, M Rossi - arXiv preprint arXiv:2102.03056, 2021 - arxiv.org
The need for single-camera 3D particle tracking methods is growing, among others, due to
the increasing focus in biomedical research often relying on single-plane microscopy …