Cation-chloride cotransporters in neuronal development, plasticity and disease
Electrical activity in neurons requires a seamless functional coupling between
plasmalemmal ion channels and ion transporters. Although ion channels have been studied …
plasmalemmal ion channels and ion transporters. Although ion channels have been studied …
Cation-chloride cotransporters and neuronal function
P Blaesse, MS Airaksinen, C Rivera, K Kaila - Neuron, 2009 - cell.com
Recent years have witnessed a steep increase in studies on the diverse roles of neuronal
cation-chloride cotransporters (CCCs). The versatility of CCC gene transcription …
cation-chloride cotransporters (CCCs). The versatility of CCC gene transcription …
K-Cl cotransporters, cell volume homeostasis, and neurological disease
K+-Cl–cotransporters (KCCs) were originally characterized as regulators of red blood cell
(RBC) volume. Since then, four distinct KCCs have been cloned, and their importance for …
(RBC) volume. Since then, four distinct KCCs have been cloned, and their importance for …
Structure of the human cation–chloride cotransport KCC1 in an outward-open state
Cation–chloride cotransporters (CCCs) catalyze electroneutral symport of Cl− with Na+
and/or K+ across membranes. CCCs are fundamental in cell volume homeostasis …
and/or K+ across membranes. CCCs are fundamental in cell volume homeostasis …
Cellular compartmentation of energy metabolism: creatine kinase microcompartments and recruitment of B-type creatine kinase to specific subcellular sites
U Schlattner, A Klaus, S Ramirez Rios, R Guzun, L Kay… - Amino Acids, 2016 - Springer
There is an increasing body of evidence for local circuits of ATP generation and
consumption that are largely independent of global cellular ATP levels. These are mostly …
consumption that are largely independent of global cellular ATP levels. These are mostly …
Developmental expression patterns of KCC2 and functionally associated molecules in the human brain
Work on rodents demonstrated that steep upregulation of KCC2, a neuron-specific Cl−
extruder of cation-chloride cotransporter (CCC) family, commences in supraspinal structures …
extruder of cation-chloride cotransporter (CCC) family, commences in supraspinal structures …
Mutations affecting GABAergic signaling in seizures and epilepsy
AS Galanopoulou - Pflügers Archiv-European Journal of Physiology, 2010 - Springer
The causes of epilepsies and epileptic seizures are multifactorial. Genetic predisposition
may contribute in certain types of epilepsies and seizures, whether idiopathic or …
may contribute in certain types of epilepsies and seizures, whether idiopathic or …
[HTML][HTML] The advantage of channeling nucleotides for very processive functions
Nucleoside triphosphate (NTP) s, like ATP (adenosine 5'-triphosphate) and GTP (guanosine
5'-triphosphate), have long been considered sufficiently concentrated and diffusible to fuel …
5'-triphosphate), have long been considered sufficiently concentrated and diffusible to fuel …
C. elegans S6K mutants require a creatine-kinase-like effector for lifespan extension
Deficiency of S6 kinase (S6K) extends the lifespan of multiple species, but the underlying
mechanisms are unclear. To discover potential effectors of S6K-mediated longevity, we …
mechanisms are unclear. To discover potential effectors of S6K-mediated longevity, we …
Knockdown of creatine kinase B inhibits ovarian cancer progression by decreasing glycolysis
Creatine kinase plays a key role in the energy homeostasis of vertebrate cells. Creatine
kinase B (CKB), a cytosolic isoform of creatine kinase, shows upregulated expression in a …
kinase B (CKB), a cytosolic isoform of creatine kinase, shows upregulated expression in a …