Emerging roles of NPQ/spexin in physiology and pathology

SY Lv, YC Zhou, XM Zhang, WD Chen… - Frontiers in …, 2019 - frontiersin.org
Spexin (SPX), also called neuropeptide Q (NPQ), is a novel endogenous neuropeptide.
Spexin gene and protein are widely expressed in central nervous system and peripheral …

Spexin as a neuroendocrine signal with emerging functions

A Ma, J Bai, M He, AOL Wong - General and comparative endocrinology, 2018 - Elsevier
Spexin (SPX), a novel peptide coevolved with the galanin/kisspeptin family, was first
identified by bioinformatics prior to its protein purification/functional studies. Its mature …

[PDF][PDF] Serum levels of spexin and kisspeptin negatively correlate with obesity and insulin resistance in women

PA Kołodziejski, E Pruszyńska-Oszmałek… - Physiological …, 2018 - biomed.cas.cz
Spexin (SPX) and kisspeptin (KISS) are novel peptides relevant in the context of regulation
of metabolism, food intake, puberty and reproduction. Here, we studied changes of serum …

Saturated long-chain fatty acid-producing bacteria contribute to enhanced colonic motility in rats

L Zhao, Y Huang, L Lu, W Yang, T Huang, Z Lin, C Lin… - Microbiome, 2018 - Springer
Background The gut microbiota is closely associated with gastrointestinal (GI) motility
disorder, but the mechanism (s) by which bacteria interact with and affect host GI motility …

Spexin: A novel regulator of adipogenesis and fat tissue metabolism

PA Kolodziejski, E Pruszynska-Oszmalek… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Spexin (SPX, NPQ) is a novel peptide involved in the regulation of energy metabolism. SPX
inhibits food intake and reduces body weight. In obese humans, SPX is the most down …

Dual role of insulin in spexin regulation: functional link between food intake and spexin expression in a fish model

A Ma, M He, J Bai, MKH Wong, WKW Ko… - …, 2017 - academic.oup.com
Spexin (SPX), a neuropeptide discovered by the bioinformatics approach, has been recently
identified as a satiety factor in a fish model. However, the functional link between feeding …

Spexin in the physiology of pancreatic islets—mutual interactions with insulin

M Sassek, PA Kolodziejski, D Szczepankiewicz… - Endocrine, 2019 - Springer
Spexin is an interesting peptide, which may play an important role in the regulation of the
metabolic homeostasis of an organism. Current knowledge on spexin expression, secretion …

Novel insights on the role of spexin as a biomarker of obesity and related cardiometabolic disease

S Kumar, RT Mankowski, SD Anton… - International Journal of …, 2021 - nature.com
Abstract Spexin (SPX) is a 14-amino acid neuropeptide, discovered recently using
bioinformatic techniques. It is encoded by the Ch12: orf39 gene that is widely expressed in …

Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction

Y Liu, L Sun, L Zheng, M Su, H Liu, Y Wei, D Li… - Naunyn-Schmiedeberg's …, 2020 - Springer
Spexin (SPX) is a novel peptide with pleiotropic functions in adipose tissue including energy
balance adjustment, fatty acid uptake, and glucose homeostasis. SPX level is closely …

Galanin peptide family regulation of glucose metabolism

P Fang, M Yu, M Shi, P Bo, Z Zhang - Frontiers in Neuroendocrinology, 2020 - Elsevier
Recent preclinical and clinical studies have indicated that the galanin peptide family may
regulate glucose metabolism and alleviate insulin resistance, which diminishes the …