Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies

BA Magnuson, GA Burdock, J Doull… - Critical reviews in …, 2007 - Taylor & Francis
Aspartame is a methyl ester of a dipeptide used as a synthetic nonnutritive sweetener in
over 90 countries worldwide in over 6000 products. The purpose of this investigation was to …

Aspartame: review of safety

HH Butchko, WW Stargel, CP Comer… - Regulatory Toxicology …, 2002 - Elsevier
Over 20 years have elapsed since aspartame was approved by regulatory agencies as a
sweetener and flavor enhancer. The safety of aspartame and its metabolic constituents was …

Clinical aspects of the ketogenic diet

AL Hartman, EPG Vining - Epilepsia, 2007 - Wiley Online Library
The ketogenic diet remains a valuable therapeutic option for patients with intractable
epilepsy. Clinical aspects of the diet's success may provide insights into epileptogenesis …

Neurophysiological symptoms and aspartame: What is the connection?

AK Choudhary, YY Lee - Nutritional neuroscience, 2018 - Taylor & Francis
Aspartame (α-aspartyl-l-phenylalanine-o-methyl ester), an artificial sweetener, has been
linked to behavioral and cognitive problems. Possible neurophysiological symptoms include …

Adverse reactions to aspartame: double-blind challenge in patients from a vulnerable population

RG Walton, R Hudak, RJ Green-Waite - Biological Psychiatry, 1993 - Elsevier
This study was designed to ascertain whether individuals with mood disorders are
particularly vulnerable to adverse effects of aspartame. Although the protocol required the …

Scientific Opinion on the re‐evaluation of aspartame (E 951) as a food additive

EFSA Panel on Food Additives and Nutrient … - Efsa …, 2013 - Wiley Online Library
Abstract The EFSA ANS Panel provides a scientific opinion on the safety of aspartame (E
951). Aspartame is a sweetener authorised as a food additive in the EU. In previous …

Aspartame: scientific evaluation in the postmarketing period

HH Butchko, WW Stargel - Regulatory Toxicology and Pharmacology, 2001 - Elsevier
Prior to marketing, the safety of the high-intensity sweetener aspartame for its intended uses
as a sweetener and flavor enhancer was demonstrated by the results of over 100 scientific …

[PDF][PDF] Natural approaches to epilepsy

AR Gaby - Alternative medicine review, 2007 - altmedrev.com
This article reviews research on the use of diet, nutritional supplements, and hormones in
the treatment of epilepsy. Potentially beneficial dietary interventions include identifying and …

Excipients in medicinal products used in gastroenterology as a possible cause of side effects

MG Ursino, E Poluzzi, C Caramella… - Regulatory Toxicology and …, 2011 - Elsevier
Although most adverse drug reactions are caused by the active substances, excipients may
sometimes affect the safety profile of a medicinal product. The aim of this review is …

Aspartame: neuropsychologic and neurophysiologic evaluation of acute and chronic effects

PA Spiers, LA Sabounjian, A Reiner, DK Myers… - The American journal of …, 1998 - Elsevier
Background: Neurobehavioral symptoms have been reported anecdotally with aspartame.
Objectives: This study sought to determine whether aspartame can disrupt cognitive …