Brown and beige adipocytes can catabolize stored energy to generate heat, and this distinct
capacity for thermogenesis could be leveraged as a therapy for metabolic diseases like …

Adipose tissue possesses the remarkable capacity to control its size and function in
response to a variety of internal and external cues, such as nutritional status and …

Non-shivering thermogenesis in brown adipose tissue is mediated by uncoupling protein 1
(UCP1), which provides a carefully regulated proton re-entry pathway across the …

Abstract Uncoupling protein 1 (UCP1) conducts protons through the inner mitochondrial
membrane to uncouple mitochondrial respiration from ATP production, thereby converting …

Brown adipocyte in brown adipose tissue (BAT) specializes in expending energy through
non-shivering thermogenesis, a process that produces heat either by uncoupling protein 1 …

Active brown adipose tissue (BAT) consumes copious amounts of glucose, yet how glucose
metabolism supports thermogenesis is unclear. By combining transcriptomics …

Mitochondrial uncoupling protein 1 (UCP1) is the crucial mechanistic component of heat
production in classical brown fat and the newly identified beige or brite fat. Thermogenesis …

Brown and brite adipocytes contribute to energy expenditure through nonshivering
thermogenesis. Though these cell types are thought to arise primarily from the de novo …

Adipocyte biology has been intensely researched in recent years due to the emergence of
obesity as a serious global health concern and because of the realization that adipose …

Decreased expression of mitochondrial frataxin (FXN) causes Friedreich's ataxia (FRDA), a
neurodegenerative disease with type 2 diabetes (T2D) as severe comorbidity. Brown …