BACKGROUND Pluripotent cells are generated by embryonic divisions that occur shortly
after fertilization. These cells are transformed into the recognizable outline of an organism …

Research using human embryos and embryoids has expanded in recent years due to
technological advances. Surveying laws and guidelines among the top research and …

Recent advances in methods to culture pluripotent stem cells to model human development
have resulted in entities that increasingly have recapitulated advanced stages of early …

During embryonic development, diffusible signaling molecules called morphogens are
thought to determine cell fates in a concentration-dependent way. Yet, in mammalian …

The inner cell mass (ICM) in blastocyst is the origin of all somatic and germ cells in
mammals and pluripotent stem cells (PSCs) in vitro. As the conserved principles between …

WNT/β-catenin signaling is crucial to all stages of life. It controls early morphogenetic events
in embryos, maintains stem cell niches in adults, and is dysregulated in many types of …

Human pluripotent stem cells (hPSCs) grow as colonies with epithelial-like features
including cell polarity and position-dependent features that contribute to symmetry breaking …

Gastrulation is an inherently complicated process involving a well-orchestrated series of
collective cellular behaviours that lead to the emergence of the body plan of the organism. A …

The paired cranial sensory organs and peripheral nervous system of vertebrates arise from
a thin strip of cells immediately adjacent to the developing neural plate. The neural plate …

To facilitate the characterization of unlabeled induced pluripotent stem cells (iPSCs) during
culture and expansion, we developed an AI pipeline for nuclear segmentation and mitosis …