Novel therapies for the treatment of cardiac fibrosis following myocardial infarction

K Raziyeva, Y Kim, Z Zharkinbekov, K Temirkhanova… - Biomedicines, 2022 - mdpi.com
Cardiac fibrosis is a common pathological consequence of most myocardial diseases. It is
associated with the excessive accumulation of extracellular matrix proteins as well as …

Cardiac metabolism in heart failure and implications for uremic cardiomyopathy

TD Nguyen, PC Schulze - Circulation Research, 2023 - Am Heart Assoc
Chronic kidney disease is associated with an increased risk for the development and
progression of cardiovascular disorders including hypertension, dyslipidemia, and coronary …

Neuregulin-1β improves uremic cardiomyopathy and renal dysfunction in rats

M Sárközy, S Watzinger, ZZA Kovács, E Acar… - Basic to Translational …, 2023 - jacc.org
Chronic kidney disease is a global health problem affecting 10% to 12% of the population.
Uremic cardiomyopathy is often characterized by left ventricular hypertrophy, fibrosis, and …

Investigation of the antihypertrophic and antifibrotic effects of losartan in a rat model of radiation-induced heart disease

MG Kovács, ZZA Kovács, Z Varga, G Szűcs… - International Journal of …, 2021 - mdpi.com
Radiation-induced heart disease (RIHD) is a potential late side-effect of thoracic
radiotherapy resulting in left ventricular hypertrophy (LVH) and fibrosis due to a complex …

The kisspeptin-1 receptor antagonist peptide-234 aggravates uremic cardiomyopathy in a rat model

H Dinh, ZZA Kovács, F Márványkövi, M Kis… - Scientific Reports, 2023 - nature.com
Uremic cardiomyopathy is characterized by diastolic dysfunction, left ventricular hypertrophy
(LVH), and fibrosis. Dysregulation of the kisspeptin receptor (KISS1R)-mediated pathways …

Cardiomyopathy in chronic kidney disease: clinical features, biomarkers and the contribution of murine models in understanding pathophysiology

CVC Junho, J Frisch, J Soppert… - Clinical Kidney …, 2023 - academic.oup.com
The cardiorenal syndrome (CRS) is described as a multi‐organ disease encompassing
bidirectionally heart and kidney. In CRS type 4, chronic kidney disease (CKD) leads to …

Exercise training worsens cardiac performance in males but does not change ejection fraction and improves hypertrophy in females in a mouse model of metabolic …

ME Tóth, M Sárközy, G Szűcs, B Dukay, P Hajdu… - Biology of sex …, 2022 - Springer
Abstract Background Metabolic syndrome (MetS) refers to a cluster of co-existing cardio-
metabolic risk factors, including visceral obesity, dyslipidemia, hyperglycemia with insulin …

Chronic kidney disease may evoke anxiety by altering CRH expression in the amygdala and tryptophan metabolism in rats

KE Ibos, É Bodnár, H Dinh, M Kis… - … -European Journal of …, 2024 - Springer
Chronic kidney disease (CKD) is associated with anxiety; however, its exact mechanism is
not well understood. Therefore, the aim of the present study was to assess the effect of …

Investigation of the antiremodeling effects of losartan, mirabegron and their combination on the development of doxorubicin-induced chronic cardiotoxicity in a rat …

M Freiwan, MG Kovács, ZZA Kovács, G Szűcs… - International Journal of …, 2022 - mdpi.com
Despite the effectiveness of doxorubicin (DOXO) as a chemotherapeutic agent, dose-
dependent development of chronic cardiotoxicity limits its application. The angiotensin-II …

Cilostazol attenuates mirabegron-induced hepatic and renal toxicity in rats: regulation of metabolic, oxidative, and inflammatory pathways

MM Anwar, IM Ibrahim Laila - Archives of Physiology and …, 2024 - Taylor & Francis
Background Mirabegron (MIRG) is a type of β3 adrenoceptor agonist that is considered an
alternative therapy for the treatment of overactive bladder (OAB) symptoms. Cilostazol (CITZ) …