Identification of a depupylation regulator for an essential enzyme in Mycobacterium tuberculosis

SC Kahne, JH Yoo, J Chen, K Nakedi, LM Iyer… - Proceedings of the …, 2024 - pnas.org
In Mycobacterium tuberculosis (Mtb), proteins that are posttranslationally modified with a
prokaryotic ubiquitin-like protein (Pup) can be degraded by bacterial proteasomes. A single …

Probing the structural heterogeneity of Pup ligase PafA using H/D exchange mass spectrometry

A Plourde, JC Ogata-Bean, S Vahidi - bioRxiv, 2024 - biorxiv.org
The Pup-proteasome system (PPS) is a unique bacterial proteolytic pathway found in some
bacterial species, including in Mycobacterium tuberculosis, that plays a vital role in …

Identification of a proteolysis regulator for an essential enzyme in Mycobacterium tuberculosis

SC Kahne, JH Yoo, J Chen, K Nakedi, LM Iyer… - bioRxiv, 2024 - biorxiv.org
In Mycobacterium tuberculosis proteins that are post-translationally modified with Pup, a
prokaryotic ubiquitin-like protein, can be degraded by proteasomes. While pupylation is …

Identification of Regulators of the Pup-Proteasome System in Mycobacterium tuberculosis

SC Kahne - 2024 - search.proquest.com
Abstract In Mycobacterium tuberculosis (Mtb) proteins post-translationally modified with
prokaryotic ubiquitin-like protein (Pup, pupylation indicated as “Pup~”) can be degraded by …