Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …

Autophagy causes the breakdown of damaged proteins and organelles to their constituent
components. The phosphatidylinositol 3‐kinase (PI3K) pathway played an important role in …

Gene therapy is an emerging and promising strategy in cancer therapy where small
interfering RNA (siRNA) system has been deployed for down-regulation of targeted gene …

Hepatocellular carcinoma (HCC) is the global leading cause of cancer-related deaths due to
the deficiency of targets for precision therapy. A new modality of epigenetic regulation has …

Primary liver cancers, including hepatocellular carcinoma (HCC) and intrahepatic
cholangiocarcinoma (iCCA), are highly lethal tumors, with high worldwide frequency and …

CSCs (Cancer stem cells) with distinct metabolic features are considered to cause HCC
(hepatocellular carcinoma) initiation, metastasis and therapeutic resistance. Here, we …

More than 90% of hepatocellular carcinoma (HCC) cases develop in the presence of fibrosis
or cirrhosis, making the tumor microenvironment (TME) of HCC distinctive due to the intricate …

The mechanisms of Myc-driven liver tumorigenesis are inadequately understood. Herein we
show that Myc-driven hepatocellular carcinoma (HCC) is dramatically aggravated in mice …

The mitochondrial‐associated membrane (MAM) is a physical platform that facilitates
communication between the endoplasmic reticulum (ER) and mitochondria. It is enriched …

MYC, a major oncogenic transcription factor, regulates target genes involved in various
pathways such as cell proliferation, metabolism and immune evasion, playing a critical role …