Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities

G Hajishengallis, T Chavakis - Nature Reviews Immunology, 2021 - nature.com
Periodontitis, a major inflammatory disease of the oral mucosa, is epidemiologically
associated with other chronic inflammation-driven disorders, including cardio-metabolic …

Mechanisms underlying the association between periodontitis and atherosclerotic disease

HA Schenkein, PN Papapanou, R Genco… - Periodontology …, 2020 - Wiley Online Library
Atherosclerosis is central to the pathology of cardiovascular diseases, a group of diseases in
which arteries become occluded with atheromas that may rupture, leading to different …

Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

SS Dominy, C Lynch, F Ermini, M Benedyk… - Science …, 2019 - science.org
Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in
the brain of Alzheimer's disease patients. Toxic proteases from the bacterium called …

Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome

FQ Pirih, S Monajemzadeh, N Singh… - Periodontology …, 2021 - Wiley Online Library
Periodontitis has been associated with many systemic diseases and conditions, including
metabolic syndrome. Metabolic syndrome is a cluster of conditions that occur concomitantly …

[HTML][HTML] Содержание про-и противовоспалительных цитокинов в динамике экспериментального пародонтита у крыс с хроническим болевым синдромом

АЕ Брусенцова, ЮД Ляшев, НВ Цыган, ТН Елие… - …, 2022 - cyberleninka.ru
Введение. Несмотря на широкое распространение пародонтита и хронических
болевых синдромов, особенно среди пациентов среднего и старшего возраста …

Porphyromonas gingivalis and Its Systemic Impact: Current Status

F Mei, M Xie, X Huang, Y Long, X Lu, X Wang, L Chen - Pathogens, 2020 - mdpi.com
The relationship between periodontitis and systemic diseases, notably including
atherosclerosis and diabetes, has been studied for several years. Porphyromonas …

Periodontal diseases and association with atherosclerotic disease

D Herrera, A Molina, K Buhlin, B Klinge - Periodontology 2000, 2020 - Wiley Online Library
Cardiovascular diseases still account for the majority of deaths worldwide, although
significant improvements in survival, after being affected by cardiovascular disease, have …

Porphyromonas gingivalis Virulence Factors and Clinical Significance in Periodontal Disease and Coronary Artery Diseases

LH Aleksijević, M Aleksijević, I Škrlec, M Šram, M Šram… - Pathogens, 2022 - mdpi.com
Porphyromonas gingivalis is a gram-negative, anaerobic bacterium that lives in the oral
cavity. It is an integral part of the oral microbiome, which includes more than 500 types of …

Porphyromonas gingivalis regulates atherosclerosis through an immune pathway

Q Ruan, P Guan, W Qi, J Li, M Xi, L Xiao… - Frontiers in …, 2023 - frontiersin.org
Atherosclerosis (AS) is a chronic inflammatory disease, involving a pathological process of
endothelial dysfunction, lipid deposition, plaque rupture, and arterial occlusion, and is one of …

Experimental evidence for the age dependence of tau protein spread in the brain

S Wegmann, RE Bennett, L Delorme, AB Robbins… - Science …, 2019 - science.org
The incidence of Alzheimer's disease (AD), which is characterized by progressive cognitive
decline that correlates with the spread of tau protein aggregation in the cortical mantle, is …