Orexins comprise two neuropeptides produced by orexin neurons in the lateral
hypothalamus and are released by extensive projections of these neurons throughout the …

Epilepsy is a common neurological disorder, affecting patients of all ages, reducing the
quality of life, and associated with several comorbidities. Sleep impairment is a frequent …

Epilepsies are common chronic neurological diseases characterized by recurrent
unprovoked seizures of central origin. The mainstay of treatment involves symptomatic …

The correlation between sleep and epilepsy has been argued over the past decades among
scientists. Although the similarities and contrasts between sleep and epilepsy had been …

Orexin peptides comprise two neuropeptides, orexin A and orexin B, that bind two G-protein
coupled receptors (GPCRs), orexin receptor 1 (OXR1) and orexin receptor 2 (OXR2) …

Orexin‐A and orexin‐B, also named hypocretin‐1 and hypocretin‐2, are two hypothalamic
neuropeptides highly conserved across mammalian species. Their effects are mediated by …

In this review study, we aimed to introduce the orexinergic system as an important signaling
pathway involved in a variety of cognitive functions such as memory, motivation, and reward …

Lateral hypothalamic (LH) hypocretin/orexin neurons (HONs) control brain-wide electrical
excitation. Abnormally high excitation produces epileptic seizures, which affect millions of …

Twenty-five years have passed since the discovery of the orexin system, during which time
we have learned more and more about it. A number of studies have been conducted …

Introduction Orexin is a neuropeptide neurotransmitter that regulates the sleep/wake cycle
produced by the lateral hypothalamus neurons. Recent studies have shown the involvement …