Abstract Background Cancer stem cells (CSCs) or tumor-initiating cells (TICs) represent a
small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the …

▪ Abstract The Myc/Max/Mad network comprises a group of transcription factors whose
distinct interactions result in gene-specific transcriptional activation or repression. A great …

Abstract CD4+ T cells and CD4+ chimeric antigen receptor (CAR) T cells display highly
variable antitumor activity in preclinical models and in patients; however, the mechanisms …

Chimeric antigen receptor (CAR) T cell therapy relies on the activity of a large pool of tumor-
targeting cytotoxic effectors. Whether CAR T cells act autonomously or require interactions …

MYC contributes to the pathogenesis of a majority of human cancers, yet strategies to
modulate the function of the c-Myc oncoprotein do not exist. Toward this objective, we have …

Deregulated expression of the MYC transcription factor occurs in most human cancers and
correlates with high proliferation, reprogrammed cellular metabolism and poor prognosis …

Abstract c-MYC (MYC) is a major driver of prostate cancer tumorigenesis and progression.
Although MYC is overexpressed in both early and metastatic disease and associated with …

Monitoring cancer and aging in vivo remains experimentally challenging. Here, we describe
a luciferase knockin mouse (p16 LUC), which faithfully reports expression of p16 INK4a, a …

The proto-oncogene c-Myc paradoxically activates both proliferation and apoptosis. In the
pathogenic state, c-Myc–induced apoptosis is bypassed via a critical, yet poorly understood …

Ligands for the NKG2D stimulatory receptor are frequently upregulated on tumor lines,
rendering them sensitive to natural killer (NK) cells, but the role of NKG2D in tumor …