Autoimmune diseases affect roughly 5-10% of the total population, with women affected
more than men. The standard treatment for autoimmune or autoinflammatory diseases had …

Antigen-specific therapy for multiple sclerosis may lead to a more effective therapy by
induction of tolerance to a wide range of myelin-derived antigens without hampering the …

Tristetraprolin (TTP) is an inducible, tandem zinc-finger mRNA binding protein that binds to
adenylate-uridylate–rich elements (AREs) in the 3′-untranslated regions (3′ UTRs) of …

Background: It is well known that the cerebrospinal fluid (CSF) concentrations of free light
chains (FLC) and immunoglobulin G (IgG) are elevated in multiple sclerosis patients (MS) …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system and is
considered to be the leading non-traumatic cause of neurological disability in young adults …

FOXP3+ regulatory T cells (Tregs) constitute a critical barrier that enforces tolerance to both
the self-peptidome and the extended-self peptidome to ensure tissue-specific resistance to …

A promising treatment for T-cell-mediated autoimmune diseases is the induction of immune
tolerance by modulating the immune response against self-antigens, an objective that may …

This study introduces a flexible format for tolerogenic vaccination that incorporates IFN-β
and neuroantigen (NAg) in the Alum adjuvant. Tolerogenic vaccination required all three …

Previous studies established that GM-CSF-deficient (Csf2-deficient) mice exhibit profound
resistance to experimental autoimmune encephalomyelitis. This study addressed whether …

Low-zone IL-2 signaling is key to understanding how CD4+ CD25high FOXP3+ regulatory T
cells (Tregs) exhibit dominance and overgrow conventional effector T cells (Tcons) that …