Approaching the catalytic mechanism of protein lysine methyltransferases by biochemical and simulation techniques
Protein lysine methyltransferases (PKMTs) transfer up to three methyl groups to the side
chains of lysine residues in proteins and fulfill important regulatory functions by controlling …
chains of lysine residues in proteins and fulfill important regulatory functions by controlling …
[HTML][HTML] Structure and function of the lysine methyltransferase SETD2 in cancer: From histones to cytoskeleton
C Michail, FR Lima, M Viguier, F Deshayes - Neoplasia, 2025 - Elsevier
SETD2 is known to be the unique histone methyltransferase responsible for the
trimethylation of the lysine 36 of histone H3 thus generating H3K36me3. This epigenetic …
trimethylation of the lysine 36 of histone H3 thus generating H3K36me3. This epigenetic …
The T1150A cancer mutant of the protein lysine dimethyltransferase NSD2 can introduce H3K36 trimethylation
Protein lysine methyltransferases (PKMTs) play essential roles in gene expression
regulation and cancer development. Somatic mutations in PKMTs are frequently observed in …
regulation and cancer development. Somatic mutations in PKMTs are frequently observed in …
Discovery of NSD2 non-histone substrates and design of a super-substrate
The human protein lysine methyltransferase NSD2 catalyzes dimethylation at H3K36. It has
very important roles in development and disease but many mechanistic features and its full …
very important roles in development and disease but many mechanistic features and its full …
Bridging bioengineering and epigenetics: from technical innovations to clinical applications
J Jacob, QC van Loosen… - Epigenetics …, 2024 - Springer
Abstract The 7th International Conference on Epigenetics & Bioengineering held in
Amsterdam, The Netherlands was a successful event covering cutting-edge research …
Amsterdam, The Netherlands was a successful event covering cutting-edge research …
[PDF][PDF] Bridging bioengineering and epigenetics: from technical innovations to clinical applications
PJ Verschure - 2024 - epicom.biomedcentral.com
Abstract The 7th International Conference on Epigenetics & Bioengineering held in
Amsterdam, The Netherlands was a successful event covering cutting-edge research …
Amsterdam, The Netherlands was a successful event covering cutting-edge research …
Molecular dynamics simulations of the substrate-and product specificity and mechanism of DNA-and protein lysine methyltransferases
P Schnee - 2024 - elib.uni-stuttgart.de
Protein Lysine Methyltransferases (PKMTs) regulate the epigenetic code of cells and their
alteration via somatic mutations are often associated with cancer. The aim of this project is to …
alteration via somatic mutations are often associated with cancer. The aim of this project is to …
Charakterisierung der Substratspezifität von Protein-Methyltransferasen
The regulation of cellular activities is a key hallmark in the development of complex life
forms. Among other factors, it is facilitated by protein lysine methyltransferases (PKMTs) …
forms. Among other factors, it is facilitated by protein lysine methyltransferases (PKMTs) …