Being the metabolic syndrome a multifactorial condition, it is difficult to find adequate
experimental models to study this pathology. The obese Zucker rats, which are homozygous …

The renin–angiotensin system (RAS) and the endothelin system have been implicated in the
pathogenesis of human cardiovascular and renal diseases, and inhibition of the RAS …

Recent studies implicate channels of the transient receptor potential vanilloid family (eg,
TRPV1) in regulating vascular tone; however, little is known about these channels in the …

This study determined alterations to nitric oxide (NO)-dependent dilation of skeletal muscle
arterioles from obese (OZR) versus lean Zucker rats (LZR). In situ cremaster muscle …

The aim of the present study was to analyze whether consumption of a fiber-supplemented
diet containing 3.5% Plantago ovata husks prevented many of the abnormalities clustered in …

Zucker rats are a useful model in which to define the mechanisms that link obesity to
diabetes and associated cardiovascular disease. The present study tests the hypothesis that …

Previous studies suggest that epoxyeicosatrienoic acids (EETs) are vasodilators of the
mesenteric artery; however, the production and regulation of EETs in the mesenteric artery …

Impaired arterial vasorelaxation, due primarily to endothelial dysfunction, is associated with
obesity. To clarify the relationship with insulin resistance and other metabolic disturbances …

Chronic increases in blood flow increase arterial diameter and NO-dependent dilation in
resistance arteries. Because endothelial dysfunction accompanies metabolic syndrome, we …

Shear stress due to blood flow is the most important force stimulating vascular endothelium.
Acute stimulation of the endothelium by shear stress induces a vasodilatation mainly due to …