GTPases are a large superfamily of evolutionarily conserved proteins involved in a variety of
fundamental cellular processes. The developmentally regulated GTP-binding protein (DRG) …

GCN1 is recognized as a factor that is essential for the activation of GCN2, which is a sensor
of amino acid starvation. This function is evolutionarily conserved from yeast to higher …

To identify addiction genes, we evaluate intravenous self-administration of cocaine or saline
in 84 inbred and recombinant inbred mouse strains over 10 days. We integrate the behavior …

Amino acids exert many biological functions, serving as allosteric regulators and
neurotransmitters, as constituents in proteins and as nutrients. GCN2-mediated …

Endothelial cell senescence is involved in endothelial dysfunction and vascular diseases.
However, the detailed mechanisms of endothelial senescence are not fully understood …

Multiple small GTPases play crucial roles in bone homeostasis by regulating the
differentiation and function of bone cells, including osteoclasts and osteoblasts. Here, we …

GCN1 is an evolutionarily-conserved ribosome-binding protein that mediates the amino acid
starvation response as well as the ribotoxic stress response. We previously demonstrated …

The cerebellum receives dopaminergic innervation and expresses the five types of
described dopaminergic receptors. The cerebellar function involves both motor movement …

The human brain contains 86 billion neurons [1], which are connected to thousands of other
neurons and thereby function in a complex spatiotemporal organization that forms the …

To identify genetic pathways for addiction, we analyzed intravenous self-administration of
cocaine or saline in a panel of 84 inbred and recombinant inbred mouse strains over 10 …