Stress and Hypothalamic–Pituitary–Adrenal (HPA) axis dysregulation play a major role in
various pathophysiological processes associated with both mood disorders and suicidal …

About one million suicides and ten million suicide attempts occur worldwide each year.
Suicide is not simply a response to stress, but generally a complication of a psychiatric …

Objective: Suicide, a major cause of death worldwide, has distinct biological underpinnings.
The authors review and synthesize the research literature on biomarkers of suicide, with the …

Corticotropin-releasing hormone (CRH) plays a central role in the regulation of the
hypothalamic-pituitary-adrenal (HPA)-axis, ie, the final common pathway in the stress …

Suicide ranks among the leading causes of death around the world and takes a heavy
emotional and public health toll on most societies. Both distal and proximal factors contribute …

Depression and suicidal behavior have recently been shown to be associated with
disturbances in structural and synaptic plasticity. Brain-derived neurotrophic factor (BDNF) …

Stress activates a complex network of hormones known as the hypothalamic–pituitary–
adrenal (HPA) axis. The HPA axis is dysregulated in chronic stress and psychiatric …

The adrenal gland is an essential stress-responsive organ that is part of both the
hypothalamic-pituitary-adrenal axis and the sympatho-adrenomedullary system. Chronic …

Suicide and related behaviors are complex phenomena associated with different risk factors.
Although most individuals who display suicidal behavior do not have a history of early-life …

Background: There has been an increase in deaths by suicide in old age in the last decade.
Depression and suicide in the elderly, 60 years and above, is a major global public health …