Protein lysine methylation is a distinct posttranslational modification that causes minimal
changes in the size and electrostatic status of lysine residues. Lysine methylation plays …

Epigenetics play a crucial role in gene regulation and cellular processes. Most importantly,
its dysregulation can contribute to the development of tumors. Epigenetic modifications, such …

The nuclear receptor–binding SET Domain (NSD) family of histone H3 lysine 36
methyltransferases is comprised of NSD1, NSD2 (MMSET/WHSC1), and NSD3 (WHSC1L1) …

Nuclear receptor-binding SET domain 2 (NSD2) is a histone lysine methyltransferase
(HKMTase), which is mainly responsible for the di-methylation of lysine residues on …

Protein lysine methyltransferases (PKMTs) transfer up to three methyl groups to the side
chains of lysine residues in proteins and fulfill important regulatory functions by controlling …

Malignant solid tumors are the leading cause of death in humans, and epigenetic regulation
plays a significant role in studying the mechanism of human solid tumors. Recently, histone …

The evolutionarily conserved Trithorax group protein Ash1 is a SET domain histone
methyltransferase that mono-and dimethylates lysine 36 of histone H3 (H3K36). Ash1 forms …

Human methionine S-adenosyltransferase (MAT2A) catalyzes the formation of S-
adenosylmethionine (SAM) from ATP and methionine. Synthetic lethal genetic analysis has …

Histone lysine methylation plays an important role in the regulation of ventricular
remodelling. NSD 2 is involved in many types of tumours through enhancing H3K36me2 …

Reversing aberrant protein methylation levels is widely recognized as a key focus in cancer
therapy. As an essential lysine methylation regulator, NSD2 (Nuclear receptor-binding SET …