One of the hallmarks of cancer‐related inflammation is the recruitment of monocyte‐
macrophage lineage cells to the tumor microenvironment. These tumor infiltrating myeloid …

Sepsis is a frequent complication in immunosuppressed cancer patients and hematopoietic
stem cell transplant recipients that is associated with high morbidity and mortality rates. The …

Sepsis and cancer share a number of pathophysiological features, and both result from the
inability of the host's immune system to cope with the initial insult (tissue invasion by …

Upon exposure to different stimuli, resting macrophages undergo classical or alternative
polarization into distinct phenotypes that can cause fatal dysfunction in a large range of …

Recently, it has been described that programmed cell death protein 1 (PD-1) overexpressing
melanoma cells are highly aggressive. However, until now it has not been defined which …

Sepsis-induced immune dysfunctions are likely to impact on malignant tumor growth.
Sequential sepsis-then-cancer models of tumor transplantation in mice recovering from …

The therapeutic use of the immune system to specifically attack tumours has been a long‐
standing vision among tumour immunologists. Recently, the use of checkpoint inhibitors to …

By phagocytosing cancer cells and their cellular debris, macrophages play a critical role in
nonspecific defense (innate immunity) and, as antigen presenters, they help initiate specific …

Methods Core genes common to both sepsis and cancer were identified using pediatric
sepsis datasets (GEO: GSE26378, GSE4607, GSE8121 and GSE13904) and cancer …

Methods Common core genes were identified from sepsis datasets (GEO: GSE26378,
GSE4607, GSE8121 and GSE13904) and cancer databases (TCGA: BRCA, COADREAD …