The skin protects the body from unwanted influences from the environment as well as
excessive water loss. The barrier function of the skin is located in the stratum corneum (SC) …

The barrier function of the skin is primarily located in the stratum corneum (SC), the
outermost layer of the skin. The SC is composed of dead cells with highly organized lipid …

A hallmark of atopic eczema (AE) is skin barrier dysfunction. Lipids in the stratum corneum
(SC), primarily ceramides, fatty acids, and cholesterol, are crucial for the barrier function, but …

The epidermis and in particular its outermost layer the stratum corneum provides terrestrial
vertebrates with a pivotal defensive barrier against water loss, xenobiotics and harmful …

The skin is the primary barrier from the outside environment, protecting the host from injury,
infectious pathogens, water loss and solar ultraviolet radiation. In this role, it is supported by …

Ceramides play an essential role in forming a permeability barrier in the skin. Atopic
dermatitis (AD) is a common chronic skin disease associated with skin barrier dysfunction …

Background The barrier dysfunction in atopic dermatitis (AD) skin correlates with stratum
corneum (SC) lipid abnormalities including reduction of global lipid content, shorter …

I review how diverse inherited and acquired abnormalities in epidermal structural and
enzymatic proteins converge to produce defective permeability barrier function and …

Atopic dermatitis (AD) is a chronic inflammatory skin disease presenting with recurrent
eczematous lesions and intense pruritus. It is common and affects both children and adults …

Mutations in the filaggrin (FLG) gene are strongly associated with common dermatological
disorders such as atopic dermatitis. However, the exact underlying pathomechanism is still …