Genetics and epigenetics in asthma

P Ntontsi, A Photiades, E Zervas, G Xanthou… - International journal of …, 2021 - mdpi.com
Asthma is one of the most common respiratory disease that affects both children and adults
worldwide, with diverse phenotypes and underlying pathogenetic mechanisms poorly …

Mechanisms of allergen immunotherapy in allergic rhinitis

G Drazdauskaitė, JA Layhadi, MH Shamji - Current allergy and asthma …, 2021 - Springer
Abstract Purpose of Review Allergic rhinitis (AR) is a chronic inflammatory immunoglobulin
(Ig) E-mediated disease of the nasal mucosa that can be triggered by the inhalation of …

Targeting cell signaling in allergic asthma

SS Athari - Signal transduction and targeted therapy, 2019 - nature.com
Asthma is chronic inflammation of the airways characterized by airway hyper-
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …

Spotlight on microRNAs in allergy and asthma

J Weidner, S Bartel, A Kılıç, UM Zissler, H Renz… - Allergy, 2021 - Wiley Online Library
In past 10 years, microRNAs (miRNAs) have gained scientific attention due to their
importance in the pathophysiology of allergic diseases and their potential as biomarkers in …

Small extracellular vesicles derived from human mesenchymal stromal cells prevent group 2 innate lymphoid cell-dominant allergic airway inflammation through …

SB Fang, HY Zhang, C Wang, BX He… - Journal of …, 2020 - Taylor & Francis
Group 2 innate lymphoid cells (ILC2s) are recently reported to play a more critical role in
allergic diseases. We previously identified that mesenchymal stromal cells (MSCs) elicited …

The ins and outs of innate and adaptive type 2 immunity

AB Molofsky, RM Locksley - Immunity, 2023 - cell.com
Type 2 immunity is orchestrated by a canonical group of cytokines primarily produced by
innate lymphoid cells, group 2, and their adaptive counterparts, CD4+ helper type 2 cells …

A guide to miRNAs in inflammation and innate immune responses

C Nejad, HJ Stunden, MP Gantier - The FEBS journal, 2018 - Wiley Online Library
The discovery of micro RNA s (miRNAs) in the early 1990's has revolutionized our thinking
of post‐transcriptional gene control. miRNAs are involved in the regulation of almost every …

[HTML][HTML] Myeloid derived suppressor cells in tumor microenvironment: Interaction with innate lymphoid cells

N Tumino, PF Fiore, A Pelosi, L Moretta… - Seminars in Immunology, 2022 - Elsevier
Human myeloid-derived suppressor cells (MDSC) represent a stage of immature myeloid
cells and two main subsets can be identified: monocytic and polymorphonuclear. MDSC …

[HTML][HTML] Circulating exosomal miR-17 inhibits the induction of regulatory T cells via suppressing TGFBR II expression in rheumatoid arthritis

L Wang, C Wang, X Jia, J Yu - Cellular Physiology and Biochemistry, 2018 - karger.com
Background/Aims: A reduced prevalence of circulating regulatory T cells (Tregs) is a
hallmark of inflammatory rheumatoid arthritis (RA). However, the underlying mechanisms of …

[HTML][HTML] Pulmonary group 2 innate lymphoid cells: surprises and challenges

MR Starkey, ANJ McKenzie, GT Belz, PM Hansbro - Mucosal immunology, 2019 - Elsevier
Group 2 innate lymphoid cells (ILC2s) are a recently described subset of innate lymphocytes
with important immune and homeostatic functions at multiple tissue sites, especially the …