Barriers between circulation and the central nervous system (CNS) play a key role in the
development and modulation of CNS immune responses. Structural variations in the …

The increasing occurrence of obesity has become a significant public health concern.
Individuals with obesity have higher prevalence of heart disease, stroke, osteoarthritis …

The brain microvascular network is comprised of capillaries, arterioles and venules, all of
which retain–although to a different extent–blood-brain barrier (BBB) properties. Capillaries …

Physiologically, lipopolysaccharide (LPS) is present in the bloodstream and can be bound to
several proteins for its transport (ie) LPS binding protein (LBP) and plasma lipoproteins) …

Numerous studies have reported the importance of microglial activation in various
pathological conditions, whereas little attention has been given to the point for dynamics of …

There is increasing evidence for blood–brain barrier (BBB) alterations in Parkinson's
disease (PD), the second most common neurodegenerative disorder with rapidly rising …

The blood–brain barrier (BBB) generally consists of endothelial tight junction barriers that
prevent the free entry of blood-derived substances, thereby maintaining the extracellular …

There is a resurgent interest in tanycytes, a radial glial-like cell population occupying the
floor and ventro-lateral walls of the third ventricle (3V). Tanycytes reside in close proximity to …

Astrocytes are the most numerous type of neuroglia in the brain and have a predominant
influence on the cerebrovascular system; they control perivascular homeostasis, the integrity …

The blood-brain barrier (BBB) protects the vertebrate central nervous system from harmful
blood-borne, endogenous and exogenous substances to ensure proper neuronal function …