Network medicine framework for identifying drug-repurposing opportunities for COVID-19
D Morselli Gysi, Í Do Valle, M Zitnik… - Proceedings of the …, 2021 - National Acad Sciences
The COVID-19 pandemic has highlighted the need to quickly and reliably prioritize clinically
approved compounds for their potential effectiveness for severe acute respiratory syndrome …
approved compounds for their potential effectiveness for severe acute respiratory syndrome …
From classical to new generation approaches: An excursus of-omics methods for investigation of protein-protein interaction networks
I Iacobucci, V Monaco, F Cozzolino, M Monti - Journal of proteomics, 2021 - Elsevier
Functional Proteomics aims to the identification of in vivo protein-protein interaction (PPI) in
order to piece together protein complexes, and therefore, cell pathways involved in …
order to piece together protein complexes, and therefore, cell pathways involved in …
A review of bioinformatics tools and web servers in different microarray platforms used in cancer research
Over the past decade, conventional lab work strategies have gradually shifted from being
limited to a laboratory setting towards a bioinformatics era to help manage and process the …
limited to a laboratory setting towards a bioinformatics era to help manage and process the …
[HTML][HTML] The social and structural architecture of the yeast protein interactome
Cellular functions are mediated by protein–protein interactions, and mapping the
interactome provides fundamental insights into biological systems. Affinity purification …
interactome provides fundamental insights into biological systems. Affinity purification …
Transforming the language of life: transformer neural networks for protein prediction tasks
The scientific community is rapidly generating protein sequence information, but only a
fraction of these proteins can be experimentally characterized. While promising deep …
fraction of these proteins can be experimentally characterized. While promising deep …
IID 2021: towards context-specific protein interaction analyses by increased coverage, enhanced annotation and enrichment analysis
M Kotlyar, C Pastrello, Z Ahmed, J Chee… - Nucleic acids …, 2022 - academic.oup.com
Improved bioassays have significantly increased the rate of identifying new protein-protein
interactions (PPIs), and the number of detected human PPIs has greatly exceeded early …
interactions (PPIs), and the number of detected human PPIs has greatly exceeded early …
Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell
TK Bartolec, X Vázquez-Campos… - Proceedings of the …, 2023 - National Acad Sciences
Significant recent advances in structural biology, particularly in the field of cryoelectron
microscopy, have dramatically expanded our ability to create structural models of proteins …
microscopy, have dramatically expanded our ability to create structural models of proteins …
PrePPI: a structure informed proteome-wide database of protein–protein interactions
We present an updated version of the Predicting Protein-Protein Interactions (PrePPI)
webserver which predicts PPIs on a proteome-wide scale. PrePPI combines structural and …
webserver which predicts PPIs on a proteome-wide scale. PrePPI combines structural and …
[HTML][HTML] Revealing protein-protein interactions at the transcriptome scale by sequencing
We describe PROPER-seq (protein-protein interaction sequencing) to map protein-protein
interactions (PPIs) en masse. PROPER-seq first converts transcriptomes of input cells into …
interactions (PPIs) en masse. PROPER-seq first converts transcriptomes of input cells into …
[HTML][HTML] Enzymes in the cholesterol synthesis pathway: interactomics in the cancer context
P Ershov, L Kaluzhskiy, Y Mezentsev, E Yablokov… - Biomedicines, 2021 - mdpi.com
A global protein interactome ensures the maintenance of regulatory, signaling and structural
processes in cells, but at the same time, aberrations in the repertoire of protein–protein …
processes in cells, but at the same time, aberrations in the repertoire of protein–protein …