The transcription factor Sox9 was first discovered in patients with campomelic dysplasia, a
haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 …

The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …

Creating in vitro models of diseases of the pancreatic ductal compartment requires a
comprehensive understanding of the developmental trajectories of pancreas-specific cell …

Successful strategies for treating type 1 diabetes need to restore the function of pancreatic
beta cells that are destroyed by the immune system and overcome further destruction of …

Insulin-secreting pancreatic β-cells are essential regulators of mammalian metabolism. The
absence of functional β-cells leads to hyperglycemia and diabetes, making patients …

Cell replacement in adult organs can be achieved through stem cell differentiation or the
replication or transdifferentiation of existing cells. In the adult liver and pancreas, stem cells …

Whether facultative β cell progenitors exist in the adult pancreas is a major unsolved
question. To date, lineage-tracing studies have provided conflicting results. To track β cell …

Current differentiation protocols have not been successful in reproducibly generating fully
functional human beta cells in vitro, partly due to incomplete understanding of human …

Tamoxifen (Tm)-inducible Cre recombinases are widely used to perform gene inactivation
and lineage tracing studies in mice. Although the efficiency of inducible Cre-loxP …

The mammalian pancreas is required for normal metabolism, with defects in this vital organ
commonly observed in cancer and diabetes. Development must therefore be tightly …