Big behavioral data: psychology, ethology and the foundations of neuroscience
Behavior is a unifying organismal process where genes, neural function, anatomy and
environment converge and interrelate. Here we review the current state and discuss the …
environment converge and interrelate. Here we review the current state and discuss the …
Three pillars of automated home-cage phenotyping of mice: novel findings, refinement, and reproducibility based on literature and experience
Animal models of neurodegenerative and neuropsychiatric disorders require extensive
behavioral phenotyping. Currently, this presents several caveats and the most important …
behavioral phenotyping. Currently, this presents several caveats and the most important …
[HTML][HTML] Behavioral phenotyping strategies for mutant mice
JN Crawley - Neuron, 2008 - cell.com
Comprehensive behavioral analyses of transgenic and knockout mice have successfully
identified the functional roles of many genes in the brain. Over the past 10 years, strategies …
identified the functional roles of many genes in the brain. Over the past 10 years, strategies …
Isoflurane anesthesia induced persistent, progressive memory impairment, caused a loss of neural stem cells, and reduced neurogenesis in young, but not adult …
C Zhu, J Gao, N Karlsson, Q Li… - Journal of Cerebral …, 2010 - journals.sagepub.com
Isoflurane and related anesthetics are widely used to anesthetize children, ranging from
premature babies to adolescents. Concerns have been raised about the safety of these …
premature babies to adolescents. Concerns have been raised about the safety of these …
[HTML][HTML] Assessing mouse behaviour throughout the light/dark cycle using automated in-cage analysis tools
An important factor in reducing variability in mouse test outcomes has been to develop
assays that can be used for continuous automated home cage assessment. Our experience …
assays that can be used for continuous automated home cage assessment. Our experience …
Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents
Human milk oligosaccharides (HMOs) are unique with regard to their diversity, quantity and
complexity, particularly in comparison to bovine milk oligosaccharides. HMOs are …
complexity, particularly in comparison to bovine milk oligosaccharides. HMOs are …
Hippocampal adult neurogenesis: Its regulation and potential role in spatial learning and memory
Adult neurogenesis, defined here as progenitor cell division generating functionally
integrated neurons in the adult brain, occurs within the hippocampus of numerous …
integrated neurons in the adult brain, occurs within the hippocampus of numerous …
[HTML][HTML] IntelliCage as a tool for measuring mouse behavior–20 years perspective
A Kiryk, A Janusz, B Zglinicki, E Turkes… - Behavioural Brain …, 2020 - Elsevier
Since the 1980s, we have witnessed the rapid development of genetically modified mouse
models of human diseases. A large number of transgenic and knockout mice have been …
models of human diseases. A large number of transgenic and knockout mice have been …
Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study
Establishing standard operating procedures (SOPs) as tools for the analysis of behavioral
phenotypes is fundamental to mouse functional genomics. It is essential that the tests …
phenotypes is fundamental to mouse functional genomics. It is essential that the tests …
Designing animal-friendly behavioral tests for neuroscience research: the importance of an ethological approach
Behavioral tests have three key elements:(1) a motivating factor (what motivates the animal
in the test);(2) an observable behavior (which behaviors we may expect the animal exhibits …
in the test);(2) an observable behavior (which behaviors we may expect the animal exhibits …