Dihydrotestosterone: biochemistry, physiology, and clinical implications of elevated blood levels

RS Swerdloff, RE Dudley, ST Page, C Wang… - Endocrine …, 2017 - academic.oup.com
Benefits associated with lowered serum DHT levels after 5 α-reductase inhibitor (5AR-I)
therapy in men have contributed to a misconception that circulating DHT levels are an …

British Society for Sexual Medicine guidelines on adult testosterone deficiency, with statements for UK practice

G Hackett, M Kirby, D Edwards, TH Jones… - The journal of sexual …, 2017 - academic.oup.com
Background Testosterone deficiency (TD) is an increasingly common problem with
significant health implications, but its diagnosis and management can be challenging. Aim …

Diagnosis and treatment of testosterone deficiency: recommendations from the Fourth International Consultation for Sexual Medicine (ICSM 2015)

M Khera, G Adaikan, J Buvat, S Carrier… - The journal of sexual …, 2016 - academic.oup.com
Introduction Testosterone deficiency (TD), also known as hypogonadism, is a condition
affecting a substantial proportion of men as they age. The diagnosis and management of TD …

The International Society for Sexual Medicine's process of care for the assessment and management of testosterone deficiency in adult men

JD Dean, CG McMahon, AT Guay… - The journal of sexual …, 2015 - academic.oup.com
ABSTRACT Introduction In 2014, the International Society for Sexual Medicine (ISSM)
convened a panel of experts to develop an evidence‐based process of care for the …

Long‐term testosterone therapy in hypogonadal men ameliorates elements of the metabolic syndrome: an observational, long‐term registry study

AM Traish, A Haider, G Doros… - International journal of …, 2014 - Wiley Online Library
Aim The goal of this study was to determine if long‐term testosterone (T) therapy in men with
hypogonadism, henceforth referred to as testosterone deficiency (TD), ameliorates or …

[HTML][HTML] Low free testosterone and prostate cancer risk: a collaborative analysis of 20 prospective studies

EL Watts, PN Appleby, A Perez-Cornago… - European urology, 2018 - Elsevier
Background Experimental and clinical evidence implicates testosterone in the aetiology of
prostate cancer. Variation across the normal range of circulating free testosterone …

Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction: mendelian randomisation study in UK Biobank

S Luo, SLA Yeung, JV Zhao, S Burgess, CM Schooling - bmj, 2019 - bmj.com
Objective To determine whether endogenous testosterone has a causal role in
thromboembolism, heart failure, and myocardial infarction. Design Two sample mendelian …

A new era of testosterone and prostate cancer: from physiology to clinical implications

M Khera, D Crawford, A Morales, A Salonia… - European urology, 2014 - Elsevier
Context Decades-old beliefs regarding androgens and prostate cancer (PCa) have
undergone dramatic shifts in light of modern evidence and new theoretical constructs, but …

Endogenous and exogenous testosterone and the risk of prostate cancer and increased prostate‐specific antigen (PSA) level: a meta‐analysis

P Boyle, A Koechlin, M Bota, A d'Onofrio… - BJU …, 2016 - Wiley Online Library
Objective To review and quantify the association between endogenous and exogenous
testosterone and prostate‐specific antigen (PSA) and prostate cancer. Methods Literature …

Long‐term treatment of hypogonadal men with testosterone produces substantial and sustained weight loss

F Saad, A Haider, G Doros, A Traish - Obesity, 2013 - Wiley Online Library
Objective This study analyzed the effects of normalization of serum testosterone (T) levels on
anthropometric parameters in hypogonadal men. Design and Methods Open‐label, single …