The organism as the niche: physiological states crack the code of adult neural stem cell heterogeneity

Z Chaker, E Makarouni, F Doetsch - Annual Review of Cell and …, 2024 - annualreviews.org
Neural stem cells (NSCs) persist in the adult mammalian brain and are able to give rise to
new neurons and glia throughout life. The largest stem cell niche in the adult mouse brain is …

[HTML][HTML] Complex II ambiguities—FADH2 in the electron transfer system

E Gnaiger - Journal of Biological Chemistry, 2024 - Elsevier
The prevailing notion that reduced cofactors NADH and FADH 2 transfer electrons from the
tricarboxylic acid cycle to the mitochondrial electron transfer system creates ambiguities …

Metabolic switches during development and regeneration

AI Mahmoud - Development, 2023 - journals.biologists.com
Metabolic switches are a crucial hallmark of cellular development and regeneration. In
response to changes in their environment or physiological state, cells undergo coordinated …

Mitochondrial heterogeneity and adaptations to cellular needs

M Granath-Panelo, S Kajimura - Nature Cell Biology, 2024 - nature.com
Although it is well described that mitochondria are at the epicentre of the energy demands of
a cell, it is becoming important to consider how each cell tailors its mitochondrial …

PAHs as environmental pollutants and their neurotoxic effects

P Xu, B Liu, H Chen, H Wang, X Guo, J Yuan - … and Physiology Part C …, 2024 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs), which are widely present in incompletely
combusted air particulate matter< 2.5 μm (PM2. 5), tobacco and other organic materials, can …

Autofluorescence is a biomarker of neural stem cell activation state

CS Morrow, K Tweed, S Farhadova, AJ Walsh, BP Lear… - Cell stem cell, 2024 - cell.com
Neural stem cells (NSCs) must exit quiescence to produce neurons; however, our
understanding of this process remains constrained by the technical limitations of current …

[HTML][HTML] The potential role of mitochondria in the microbiota-gut-brain axis: Implications for brain health

L Qiao, G Yang, P Wang, C Xu - Pharmacological Research, 2024 - Elsevier
Mitochondria are crucial organelles that regulate cellular energy metabolism, calcium
homeostasis, and oxidative stress responses, playing pivotal roles in brain development and …

[HTML][HTML] Inhalation Anesthetics Play a Janus-Faced Role in Self-Renewal and Differentiation of Stem Cells

X Hao, Y Li, H Gao, Z Wang, B Fang - Biomolecules, 2024 - mdpi.com
Inhalation anesthesia stands as a pivotal modality within clinical anesthesia practices.
Beyond its primary anesthetic effects, inhaled anesthetics have non-anesthetic effects …

Metabolic regulation in adult and aging skeletal muscle stem cells

V Sartorelli, V Ciuffoli - Genes & Development, 2024 - genesdev.cshlp.org
Adult stem cells maintain homeostasis and enable regeneration of most tissues.
Quiescence, proliferation, and differentiation of stem cells and their progenitors are tightly …

[HTML][HTML] Digirseophene A promotes recovery in injured developing cerebellum via AMPK/AKT/GSK3β pathway-mediated neural stem cell proliferation

X Tang, Y Huang, W Fu, P Wang, L Feng, J Yang… - Biomedicine & …, 2024 - Elsevier
Neural stem cells (NSCs) exhibit a remarkable capacity for self-renewal and have the
potential to differentiate into various neural lineage cells, which makes them pivotal in the …