A life course approach to chronic disease epidemiology
▪ Abstract A life course approach to chronic disease epidemiology uses a multidisciplinary
framework to understand the importance of time and timing in associations between …
framework to understand the importance of time and timing in associations between …
The Th1: th2 dichotomy of pregnancy and preterm labour
L Sykes, DA MacIntyre, XJ Yap, TG Teoh… - Mediators of …, 2012 - Wiley Online Library
Pregnancy is a unique immunological state in which a balance of immune tolerance and
suppression is needed to protect the fetus without compromising the mother. It has long …
suppression is needed to protect the fetus without compromising the mother. It has long …
T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells
Abstract T helper type 1 (TH1) cell development involves interferon-γ (IFN-γ) signaling
through signal transducer and activator of transcription 1 (STAT1) and interleukin-12 (IL-12) …
through signal transducer and activator of transcription 1 (STAT1) and interleukin-12 (IL-12) …
Functional and Phenotypic Plasticity of CD4+ T Cell Subsets
T Caza, S Landas - BioMed research international, 2015 - Wiley Online Library
The remarkable plasticity of CD4+ T cells allows individuals to respond to environmental
stimuli in a context‐dependent manner. A balance of CD4+ T cell subsets is critical to mount …
stimuli in a context‐dependent manner. A balance of CD4+ T cell subsets is critical to mount …
Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue
MJ Jasper, KP Tremellen… - MHR: Basic science of …, 2006 - academic.oup.com
A receptive endometrial environment requires adequate immunological tolerance to protect
the implanting embryo from maternal immune rejection. Studies in mice implicate CD4+ …
the implanting embryo from maternal immune rejection. Studies in mice implicate CD4+ …
Memory and flexibility of cytokine gene expression as separable properties of human TH1 and TH2 lymphocytes
M Messi, I Giacchetto, K Nagata, A Lanzavecchia… - Nature …, 2003 - nature.com
CD4+ T cell priming under T helper type I (TH1) or TH2 conditions gives rise to polarized
cytokine gene expression. We found that in these conditions human naive T cells acquired …
cytokine gene expression. We found that in these conditions human naive T cells acquired …
Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor
F Qi, A Li, Y Inagaki, N Kokudo, S Tamura… - International …, 2011 - Elsevier
The skin of the toad Bufo bufo gargarizans Cantor is known to be rich in bufadienolides,
peptides and alkaloids. It has been found to be a source of some extracts and biologically …
peptides and alkaloids. It has been found to be a source of some extracts and biologically …
Induction of IL-4 expression in CD4+ T cells by thymic stromal lymphopoietin
M Omori, S Ziegler - The Journal of Immunology, 2007 - journals.aai.org
The cytokine thymic stromal lymphopoietin (TSLP) has been implicated in the development
and progression of allergic inflammation in both humans and mice. Although the underlying …
and progression of allergic inflammation in both humans and mice. Although the underlying …
Epigenetics in atherosclerosis and inflammation
Introduction• Epigenetics explained‐Epigenetic alterations are reversible• Atherosclerosis•
Epigenetics and association with atherosclerosis• Epigenetic regulation of cell activity‐T …
Epigenetics and association with atherosclerosis• Epigenetic regulation of cell activity‐T …
Schistosomal extracellular vesicle‐enclosed miRNAs modulate host T helper cell differentiation
T Meningher, Y Barsheshet, Y Ofir‐Birin, D Gold… - EMBO …, 2020 - embopress.org
During the chronic stage of Schistosoma infection, the female lays fertile eggs, triggering a
strong anti‐parasitic type 2 helper T‐cell (Th2) immune response. It is unclear how this Th2 …
strong anti‐parasitic type 2 helper T‐cell (Th2) immune response. It is unclear how this Th2 …