Proteins can exist in a trinity of structures: the ordered state, the molten globule, and the
random coil. The five following examples suggest that native protein structure can …

The microtubule-based kinesin motors and actin-based myosin motors generate motions
associated with intracellular trafficking, cell division, and muscle contraction. Early studies …

Fibrotic rigidification following a myocardial infarct is known to impair cardiac output, and it is
also known that cardiomyocytes on rigid culture substrates show a progressive loss of …

Myosins constitute a large superfamily of actin-dependent molecular motors. Phylogenetic
analysis currently places myosins into 15 classes. The conventional myosins which form …

In the last two decades, considerable progress has been made in the field of molecular
biology, which has enabled a molecular-level understanding of a number of interesting …

Kinesin motors power many motile processes by converting ATP energy into unidirectional
motion along microtubules. The force-generating and enzymatic properties of conventional …

Background The molecular basis of idiopathic dilated cardiomyopathy, a primary myocardial
disorder that results in reduced contractile function, is largely unknown. Some cases of …

With the advent of technologies to obtain the complete sequence of the human genome in a
cost-effective manner, this decade and those to come will see an exponential increase in our …

Myosins and kinesins are molecular motors that hydrolyse ATP to track along actin filaments
and microtubules, respectively. Although the kinesin family includes motors that move …

The general structural features of the motor region of myosin superfamily members are now
well established, as is a subset of the structural and kinetic transitions of the actin-myosin …