Obesity as a risk factor for dementia and Alzheimer's disease: the role of leptin

JA Flores-Cordero, A Pérez-Pérez… - International journal of …, 2022 - mdpi.com
Obesity is a growing worldwide health problem, affecting many people due to excessive
saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine …

Structural brain changes associated with overweight and obesity

E Gómez-Apo, A Mondragón-Maya… - Journal of …, 2021 - Wiley Online Library
Obesity is a global health problem with a broad set of comorbidities, such as malnutrition,
metabolic syndrome, diabetes, systemic hypertension, heart failure, and kidney failure. This …

[HTML][HTML] Diet, inflammation and the gut microbiome: mechanisms for obesity-associated cognitive impairment

SJ Leigh, MJ Morris - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2020 - Elsevier
Poor diet and obesity are associated with cognitive impairment throughout adulthood, and
increased dementia risk in aging. Here we review the current literature interrogating the …

Association between midlife obesity and its metabolic consequences, cerebrovascular disease, and cognitive decline

F Morys, M Dadar, A Dagher - The Journal of Clinical …, 2021 - academic.oup.com
Context Chronic obesity is associated with several complications, including cognitive
impairment and dementia. However, we have only piecemeal knowledge of the mechanisms …

Cohort profile: the LIFE-adult-study

C Engel, K Wirkner, S Zeynalova… - International Journal …, 2023 - academic.oup.com
International Journal of Epidemiology, 2023, e66–e79 https://doi. org/10.1093/ije/dyac114
Advance Access Publication Date: 28 May 2022 Cohort Profile comprehensive molecular …

Overnutrition induced cognitive impairment: insulin resistance, gut-brain axis, and neuroinflammation

Q Zhang, K Jin, B Chen, R Liu, S Cheng… - Frontiers in …, 2022 - frontiersin.org
Overnutrition-related obesity has become a worldwide epidemic, and its prevalence is
expected to steadily rise in the future. It is widely recognized that obesity exerts negative …

Early life factors and structural brain network in children with overweight/obesity: The ActiveBrains project

P Solis-Urra, M Rodriguez-Ayllon… - Pediatric …, 2023 - nature.com
Background The aims of this study were to investigate the association of early life factors,
including birth weight, birth length, and breastfeeding practices, with structural brain …

Impact of obesity and diet on brain structure and function: A gut–brain–body crosstalk

E Medawar, AV Witte - Proceedings of the Nutrition Society, 2022 - cambridge.org
Most societies witness an ever increasing prevalence of both obesity and dementia, a
scenario related to often underestimated individual and public health burden. Overnutrition …

Associations between sleep-related symptoms, obesity, cardiometabolic conditions, brain structural alterations and cognition in the UK biobank

J Yu, F Morys, A Dagher, A Lajoie, T Gomes, EY Ock… - Sleep Medicine, 2023 - Elsevier
Objectives Sleep disturbances are increasingly recognized as adversely affecting brain
health in aging. Our aim was to investigate interrelations between subjective sleep-related …

Neuroimaging Investigations of Obesity: a Review of the Treatment of Sex from 2010

LA Kilpatrick, HM An, S Pawar, R Sood, A Gupta - Current obesity reports, 2023 - Springer
Abstract Purpose of Review To summarize the results of adult obesity neuroimaging studies
(structural, resting-state, task-based, diffusion tensor imaging) published from 2010, with a …