Proper bone remodeling necessarily requires that osteoblasts reconstruct the bone that
osteoclasts have resorbed. However, the cellular events connecting resorption to …

The balance between bone forming cells (osteoblasts/osteocytes) and bone resorbing cells
(osteoclasts) plays a crucial role in tissue homeostasis and bone repair. Several hormones …

The impact of bone cell activation on bacterially-induced osteolysis remains elusive. Here,
we show that matrix-embedded osteocytes stimulated with bacterial pathogen-associated …

Osteoblasts are the only cells that can give rise to bones in vertebrates. Thus, one of the
most important functions of these metabolically active cells is mineralized matrix production …

Cortical bone structure is a crucial determinant of bone strength, yet for many years studies
of novel genes and cell signalling pathways regulating bone strength have focused on the …

Denosumab is a monoclonal anti-RANKL antibody that inhibits bone resorption, increases
bone mass, and reduces fracture risk. Denosumab discontinuation causes an extensive …

Primary osteoporosis is closely linked to hormone deficiency, which disrupts the balance of
bone remodeling. It affects postmenopausal women but also significantly impacts older men …

Osteochondroprogenitors are crucial for embryonic bone development and postnatal
processes such as bone repair in response to fracture injury, and their dysfunction may …

Abstract Purpose of Review The adult skeleton contains stem cells involved in growth,
homeostasis, and healing. Mesenchymal or skeletal stem cells are proposed to provide …

To verify whether PTH acts on bone-specific blood vessels and on cells surrounding these
blood vessels, 6-week-old male mice were subjected to vehicle (control group) or hPTH [1 …