Non-alcoholic fatty liver disease (NAFLD) pathogenesis and natural products for prevention and treatment

X Guo, X Yin, Z Liu, J Wang - International journal of molecular sciences, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease,
affecting approximately one-quarter of the global population, and has become a world public …

The Common Cichory (Cichorium intybus L.) as a Source of Extracts with Health-Promoting Properties—A Review

K Janda, I Gutowska, M Geszke-Moritz, K Jakubczyk - Molecules, 2021 - mdpi.com
Natural products are gaining more interest recently, much of which focuses on those derived
from medicinal plants. The common chicory (Cichorium intybus L.), of the Astraceae family …

Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling

J Zhong, X He, X Gao, Q Liu, Y Zhao, Y Hong… - Nature …, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is usually characterized with disrupted bile acid
(BA) homeostasis. However, the exact role of certain BA in NAFLD is poorly understood …

[PDF][PDF] Medical importance of Cichorium intybus–A review

AE Al-Snafi - IOSR Journal of Pharmacy, 2016 - researchgate.net
Phytochemical analysis showed that the different parts Cichorium intybus contained
sesquiterpene lactones (especially lactucin, lactucopicrin, 8-desoxy lactucin, guaianolid …

[HTML][HTML] A new perspective on NAFLD: Focusing on the crosstalk between peroxisome proliferator-activated receptor alpha (PPARα) and farnesoid X receptor (FXR)

S Zhou, H You, S Qiu, D Yu, Y Bai, J He, H Cao… - Biomedicine & …, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is primarily caused by abnormal lipid metabolism
and the accumulation of triglycerides in the liver. NAFLD is also associated with hepatic …

Cichorium intybus: Traditional Uses, Phytochemistry, Pharmacology, and Toxicology

RA Street, J Sidana, G Prinsloo - … ‐based Complementary and …, 2013 - Wiley Online Library
The genus Cichorium (Asteraceae) is made up of six species with major geographical
presence in Europe and Asia. Cichorium intybus, commonly known as chicory, is well known …

Chicoric Acid Ameliorates Nonalcoholic Fatty Liver Disease via the AMPK/Nrf2/NFκB Signaling Pathway and Restores Gut Microbiota in High‐Fat‐Diet‐Fed Mice

X Ding, T Jian, J Li, H Lv, B Tong, J Li… - Oxidative Medicine …, 2020 - Wiley Online Library
This study examines the effects of chicoric acid (CA) on nonalcoholic fatty liver disease
(NAFLD) in high‐fat‐diet‐(HFD‐) fed C57BL/6 mice. CA treatment decreased body weight …

Antidiabetic Potency, Antioxidant Effects, and Mode of Actions of Citrus reticulata Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin in Nicotinamide …

AM Ali, MA Gabbar, SM Abdel-Twab… - Oxidative medicine …, 2020 - Wiley Online Library
This study is aimed at assessing the antihyperglycemic, antihyperlipidemic, and antioxidant
effects of Citrus reticulata (C. reticulata) fruit peel hydroethanolic extract and two flavonoids …

Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease research

J Willebrords, IVA Pereira, M Maes, SC Yanguas… - Progress in lipid …, 2015 - Elsevier
Non-alcoholic fatty liver disease encompasses a spectrum of liver diseases, including
simple steatosis, steatohepatitis, liver fibrosis and cirrhosis and hepatocellular carcinoma …

Polyphenols as potential metabolism mechanisms regulators in liver protection and liver cancer prevention

S Li, S Yin, H Ding, Y Shao, S Zhou, W Pu… - Cell …, 2023 - Wiley Online Library
Background Liver cancer is one of the common malignancies. The dysregulation of
metabolism is a driver of accelerated tumourigenesis. Metabolic changes are well …