A three-dimensional Alzheimer's disease cell culture model using iPSC-derived neurons carrying A246E mutation in PSEN1

MA Hernández-Sapiéns, EE Reza-Zaldívar… - Frontiers in cellular …, 2020 - frontiersin.org
Alzheimer's disease (AD) is a chronic brain disorder characterized by progressive
intellectual decline and memory and neuronal loss, caused mainly by extracellular …

NANOG and LIN28 dramatically improve human cell reprogramming by modulating LIN41 and canonical WNT activities

L Wang, Y Su, C Huang, Y Yin, A Chu… - Biology …, 2019 - journals.biologists.com
Human cell reprogramming remains extremely inefficient and the underlying mechanisms by
different reprogramming factors are elusive. We found that NANOG and LIN28 (NL) …

Molecular profiling associated with calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2)-mediated carcinogenesis in gastric cancer

MA Najar, PK Modi, P Ramesh… - Journal of proteome …, 2021 - ACS Publications
Gastric cancer is the fifth most common cancer and the third leading cause of cancer-related
death worldwide. We showed previously that calcium/calmodulin-dependent protein kinase …

Generation of stable integration‐free pig induced pluripotent stem cells under chemically defined culture condition

Q Zhu, F Wang, D Gao, J Gao, G Li, D Jiao… - Cell …, 2023 - Wiley Online Library
Genome integration‐free pig induced pluripotent stem cells (iPSCs) bring tremendous value
in pre‐clinical testing of regenerative medicine, as well as conservation and exploitation of …

[HTML][HTML] Promotion of ovarian cancer cell invasion, migration and colony formation by the miR‑21/Wnt/CD44v6 pathway

Y Wang, X Yang, M Yuan, S Xian… - Oncology …, 2019 - spandidos-publications.com
Ovarian cancer (OC) has the highest mortality rate among female malignant tumors, and OC
commonly relapses and metastasizes. The mechanisms underlying the occurrence and …

Potential biomarkers for testicular germ cell tumour: Risk assessment, diagnostic, prognostic and monitoring of recurrence

N Lakpour, K Saliminejad, R Ghods… - Andrologia, 2021 - Wiley Online Library
Testicular germ cell tumour (TGCT) is considered a relatively rare malignancy usually
occurring in young men between 15 and 35 years of age, and both genetic and …

An orally antitumor chalcone hybrid inhibited HepG2 cells growth and migration as the tubulin binding agent

W Yan, C Xiangyu, L Ya, W Yu, X Feng - Investigational New Drugs, 2019 - Springer
Liver cancer is a kind of high mortality cancer due to the difficulty of early diagnosis. It is
necessary to develop the anticancer agents to treat liver cancer. Here, a novel chalcone …

Assessment of the hematopoietic differentiation potential of human pluripotent stem cells in 2D and 3D culture systems

GA Mora-Roldan, D Ramirez-Ramirez, R Pelayo… - Cells, 2021 - mdpi.com
Background. In vitro methods for hematopoietic differentiation of human pluripotent stem
cells (hPSC) are a matter of priority for the in-depth research into the mechanisms of early …

FOXH1 is regulated by NANOG and LIN28 for early-stage reprogramming

L Wang, Y Su, C Huang, Y Yin, J Zhu, A Knupp… - Scientific Reports, 2019 - nature.com
FOXH1 is a primitive-streak specifier and ACTIVIN co-effector that plays an important role in
development, and positively regulates the generation of human induced pluripotent stem …

WNT7B promotes cancer progression via WNT/β-catenin signaling pathway and predicts a poor prognosis in oral squamous cell carcinoma

Y Li, L Huang, Q Hu, K Zheng, Y Yan, T Lan, D Zheng… - BMC Oral Health, 2024 - Springer
Background WNT7B is a glycoprotein that plays a crucial role in tumorigenesis. This study
aimed to investigate the role of WNT7B in oral squamous cell carcinoma (OSCC). Methods …