Perspective: the potential of pyrazole-based compounds in medicine

FK Keter, J Darkwa - Biometals, 2012 - Springer
Pyrazoles are widely used as core motifs for a large number of compounds for various
applications such as catalysis, agro-chemicals, building blocks of other compounds and in …

[PDF][PDF] Pyrazoline derivatives: a worthy insight into the recent advances and potential pharmacological activities

MA Rahman, AA Siddiqui - Int J Pharm Sci Drug Res, 2010 - researchgate.net
Pyrazolines display a broad spectrum of potential pharmacological activities and are present
in a number of pharmacologically active molecules such as phenazone/amidopyrene …

Design, synthesis and biological evaluation of some pyrazole derivatives as anti-inflammatory-antimicrobial agents

AA Bekhit, T Abdel-Aziem - Bioorganic & medicinal chemistry, 2004 - Elsevier
The synthesis of novel series of structurally related 1H-pyrazolyl derivatives is described. All
the newly synthesized compounds were tested for their in vivo anti-inflammatory activity by …

Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents

AA Bekhit, HMA Ashour, YSA Ghany… - European journal of …, 2008 - Elsevier
Four series of pyrazolyl benzenesulfonamide derivatives have been synthesized. The first
series was prepared by cyclization of the intermediate N, N-dimethylaminomethylene-4 [3 …

Synthesis of some novel pyrazolo [3, 4-d] pyrimidine derivatives as potential antimicrobial agents

BS Holla, M Mahalinga, MS Karthikeyan… - Bioorganic & medicinal …, 2006 - Elsevier
The reaction of 4-hydrazino-8-(trifluoromethyl) quinoline (2) with
ethoxymethylenecyanoacetate afforded ethyl 5-amino-1-[8-(trifluoromethyl) quinolin-4-yl]-1H …

Design and synthesis of some substituted 1H-pyrazolyl-thiazolo [4, 5-d] pyrimidines as anti-inflammatory–antimicrobial agents

AA Bekhit, HTY Fahmy, SAF Rostom… - European journal of …, 2003 - Elsevier
The synthesis of two novel series of structurally related 1H-pyrazolyl derivatives of thiazolo
[4, 5-d] pyrimidines is described. All the newly synthesised compounds were examined for …

Polysubstituted pyrazoles, part 5. Synthesis of new 1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid hydrazide analogs and some derived ring systems. A …

SAF Rostom, MA Shalaby, MA El-Demellawy - European Journal of …, 2003 - Elsevier
A novel series of 1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid hydrazide
analogs and some derived 4-substituted-1, 2, 4-triazolin-3-thiones, 2-substituted-1, 3, 4 …

Some 3-thioxo/alkylthio-1, 2, 4-triazoles with a substituted thiourea moiety as possible antimycobacterials

I Küçükgüzel, SG Küçükgüzel, S Rollas… - Bioorganic & medicinal …, 2001 - Elsevier
A series of novel N-alkyl/aryl-N′-[4-(4-alkyl/aryl-2, 4-dihydro-3H-1, 2, 4-triazole-3-thione-5-
yl) phenyl] thioureas 1–19 and three S-alkylated representatives of the former, N-alkyl/aryl …

Recent developments on triazole nucleus in anticonvulsant compounds: a review

MX Song, XQ Deng - Journal of enzyme inhibition and medicinal …, 2018 - Taylor & Francis
Epilepsy is one of the common diseases seriously threatening life and health of human.
More than 50 million people are suffering from this condition and anticonvulsant agents are …

Synthesis and antimicrobial activities of novel 1, 5-diaryl pyrazoles

RV Ragavan, V Vijayakumar, NS Kumari - European journal of medicinal …, 2010 - Elsevier
Novel 1, 5-diaryl pyrazole derivatives viz. 5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-
3-carboxamides (2a–e, 3, 3a–f), 2-(5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-yl) …