Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …

Proper subcellular localization is crucial for the functioning of biomacromolecules, including
proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the …

Mutations in the RNA-binding protein FUS cause familial amyotropic lateral sclerosis (ALS).
Several mutations that affect the proline-tyrosine nuclear localization signal (PY-NLS) of …

Abstract Exportin-1 (XPO1/CRM1) plays a central role in the nuclear-to-cytoplasmic transport
of hundreds of proteins and contributes to other cellular processes, such as centrosome …

Autophagy is a vital cellular mechanism that benefits cellular maintenance and survival
during cell stress. It can eliminate damaged or long-lived organelles and improperly folded …

Hepatitis B virus (HBV) is a global pathogen. We report here that the cellular CRM1
machinery can mediate nuclear export of entire HBV core (HBc) particles containing …

The phosphorylation of three highly conserved serine residues S23, S24, and S25 (S‐S‐S
motif) has been previously identified in NEP of influenza virus. However, it remains obscure …

Abstract Background OsWRKY62 and OsWRKY76, two close members of WRKY
transcription factors, function together as transcriptional repressors. OsWRKY62 is …

Abstract Exportin-1 (XPO1) is an essential nuclear export receptor that is involved in the
pathogenesis of multiple tumors. However, the role of XPO1 in diffuse large B-cell lymphoma …

Nuclear export factor chromosome region maintenance 1 (CRM1) is an attractive anticancer
and antiviral drug target that spurred several research efforts to develop its inhibitor …