Current therapeutic vaccination and immunotherapy strategies for HPV-related diseases

JG Skeate, AW Woodham, MH Einstein… - Human vaccines & …, 2016 - Taylor & Francis
Carcinomas of the anogenital tract, in particular cervical cancer, remains one of the most
common cancers in women, and represent the most frequent gynecological malignancies …

Immunology of HPV-mediated cervical cancer: current understanding

B Jee, R Yadav, S Pankaj, SK Shahi - International Reviews of …, 2021 - Taylor & Francis
Human papilloma virus (HPV) has emerged as a primary cause of cervical cancer
worldwide. HPV is a relatively small (55 nm in diameter) and non-enveloped virus …

Human papilloma virus and breast cancer: the role of inflammation and viral expressed proteins

N Khodabandehlou, S Mostafaei, A Etemadi… - BMC cancer, 2019 - Springer
Background Breast cancer is currently the most common neoplasm diagnosed in women
globally. There is a growing body of evidence to suggest that human papillomavirus (HPV) …

The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer

M Kawano, S Mabuchi, Y Matsumoto, T Sasano… - Scientific reports, 2015 - nature.com
Granulocyte-colony stimulating factor (G-CSF) producing malignant tumor has been
reported to occur in various organs and has been associated with poor clinical outcome. The …

B lymphocytes can be activated to act as antigen presenting cells to promote anti-tumor responses

RAM Rossetti, NPC Lorenzi, K Yokochi, MBSF Rosa… - PloS one, 2018 - journals.plos.org
Immune evasion by tumors includes several different mechanisms, including the inefficiency
of antigen presenting cells (APCs) to trigger anti-tumor T cell responses. B lymphocytes may …

Immunological network analysis in HPV associated head and neck squamous cancer and implications for disease prognosis

X Chen, B Yan, H Lou, Z Shen, F Tong, A Zhai… - Molecular …, 2018 - Elsevier
Abstract Human papillomavirus-positive (HPV+) head and neck squamous cell cancer
(HNSCC) exhibits a better prognosis than HPV-negative (HPV−) HNSCC. This difference …

Activities of stromal and immune cells in HPV-related cancers

MR Barros, CML de Melo, MLCMGR Barros… - Journal of Experimental …, 2018 - Springer
The immune system is composed of immune as well as non-immune cells. As this system is
a well-established component of human papillomavirus-(HPV)-related carcinogenesis, high …

Lactate secreted by cervical cancer cells modulates macrophage phenotype

SC Stone, RAM Rossetti, KLF Alvarez… - Journal of leukocyte …, 2019 - academic.oup.com
Cervical cancer continues to be a public health problem in developing countries. Previous
studies have shown that cervical cancer cells display markers of aerobic glycolysis …

[HTML][HTML] Modulation of antigen presenting cell functions during chronic HPV infection

AA Bashaw, GR Leggatt, J Chandra, ZK Tuong… - Papillomavirus …, 2017 - Elsevier
High-risk human papillomaviruses (HR-HPV) infect basal keratinocytes, where in some
individuals they evade host immune responses and persist. Persistent HR-HPV infection of …

Human papillomavirus and the stroma: bidirectional crosstalk during the virus life cycle and carcinogenesis

ME Spurgeon, PF Lambert - Viruses, 2017 - mdpi.com
Human papillomaviruses (HPVs) are double-stranded DNA (dsDNA) tumor viruses that are
causally associated with human cancers of the anogenital tract, skin, and oral cavity. Despite …