A few good peptides: MHC class I-based cancer immunosurveillance and immunoevasion
The remarkable success of immune checkpoint inhibitors demonstrates the potential of
tumour-specific CD8+ T cells to prevent and treat cancer. Although the number of lives …
tumour-specific CD8+ T cells to prevent and treat cancer. Although the number of lives …
Alternative tumour-specific antigens
The study of tumour-specific antigens (TSAs) as targets for antitumour therapies has
accelerated within the past decade. The most commonly studied class of TSAs are those …
accelerated within the past decade. The most commonly studied class of TSAs are those …
[HTML][HTML] MHCflurry 2.0: improved pan-allele prediction of MHC class I-presented peptides by incorporating antigen processing
Computational prediction of the peptides presented on major histocompatibility complex
(MHC) class I proteins is an important tool for studying T cell immunity. The data available to …
(MHC) class I proteins is an important tool for studying T cell immunity. The data available to …
A large peptidome dataset improves HLA class I epitope prediction across most of the human population
Prediction of HLA epitopes is important for the development of cancer immunotherapies and
vaccines. However, current prediction algorithms have limited predictive power, in part …
vaccines. However, current prediction algorithms have limited predictive power, in part …
NetMHCpan-4.0: improved peptide–MHC class I interaction predictions integrating eluted ligand and peptide binding affinity data
Cytotoxic T cells are of central importance in the immune system's response to disease.
They recognize defective cells by binding to peptides presented on the cell surface by MHC …
They recognize defective cells by binding to peptides presented on the cell surface by MHC …
Noncoding regions are the main source of targetable tumor-specific antigens
CM Laumont, K Vincent, L Hesnard… - Science translational …, 2018 - science.org
Tumor-specific antigens (TSAs) represent ideal targets for cancer immunotherapy, but few
have been identified thus far. We therefore developed a proteogenomic approach to enable …
have been identified thus far. We therefore developed a proteogenomic approach to enable …
[HTML][HTML] Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction
The accurate selection of neoantigens that bind to class I human leukocyte antigen (HLA)
and are recognized by autologous T cells is a crucial step in many cancer immunotherapy …
and are recognized by autologous T cells is a crucial step in many cancer immunotherapy …
Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy
Functional diversity of the highly polymorphic human leukocyte antigen class I (HLA-I) genes
underlies successful immunologic control of both infectious disease and cancer. The …
underlies successful immunologic control of both infectious disease and cancer. The …
The peptide vaccine of the future
The approach of peptide-based anticancer vaccination has proven the ability to induce
cancer-specific immune responses in multiple studies for various cancer entities. However …
cancer-specific immune responses in multiple studies for various cancer entities. However …
Most non-canonical proteins uniquely populate the proteome or immunopeptidome
Combining RNA sequencing, ribosome profiling, and mass spectrometry, we elucidate the
contribution of non-canonical translation to the proteome and major histocompatibility …
contribution of non-canonical translation to the proteome and major histocompatibility …