Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …

The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …

Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

The SLC22 family contains 13 functionally characterized human plasma membrane proteins
each with 12 predicted α-helical transmembrane domains. The family comprises organic …

The body is equipped with broad-specificity transporters for the excretion and distribution of
endogeneous organic cations and for the uptake, elimination and distribution of cationic …

Primary carnitine deficiency, because of a defect of the tissue plasma membrane carnitine
transporters, causes critical symptoms. However, the transporter has not been molecularly …

The SLC22 family comprises organic cation transporters (OCTs), zwitterion/cation
transporters (OCTNs), and organic anion transporters (OATs). These transporters contain 12 …

In 1998 we updated earlier descriptions of the largest family of secondary transport carriers
found in living organisms, the major facilitator superfamily (MFS). Seventeen families of …

Renal excretion of organic anions and cations is mediated by the organic ion transporter
family (SLC22A). In this study, the mRNA levels of the organic ion transporters were …

For the elimination of environmental toxins and metabolic waste products, the body is
equipped with a range of broad-specificity transporters that are generally present in the liver …