Myopia

PN Baird, SM Saw, C Lanca, JA Guggenheim… - Nature reviews Disease …, 2020 - nature.com
Myopia, also known as short-sightedness or near-sightedness, is a very common condition
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …

The epidemics of myopia: aetiology and prevention

IG Morgan, AN French, RS Ashby, X Guo, X Ding… - Progress in retinal and …, 2018 - Elsevier
There is an epidemic of myopia in East and Southeast Asia, with the prevalence of myopia in
young adults around 80–90%, and an accompanying high prevalence of high myopia in …

[HTML][HTML] IMI–Report on experimental models of emmetropization and myopia

D Troilo, EL Smith, DL Nickla, R Ashby… - … & visual science, 2019 - iovs.arvojournals.org
The results of many studies in a variety of species have significantly advanced our
understanding of the role of visual experience and the mechanisms of postnatal eye growth …

Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression

JE Craig, X Han, A Qassim, M Hassall… - Nature …, 2020 - nature.com
Glaucoma, a disease characterized by progressive optic nerve degeneration, can be
prevented through timely diagnosis and treatment. We characterize optic nerve photographs …

Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia

PG Hysi, H Choquet, AP Khawaja, R Wojciechowski… - Nature …, 2020 - nature.com
Refractive errors, in particular myopia, are a leading cause of morbidity and disability
worldwide. Genetic investigation can improve understanding of the molecular mechanisms …

HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease

LD Ward, M Kellis - Nucleic acids research, 2016 - academic.oup.com
More than 90% of common variants associated with complex traits do not affect proteins
directly, but instead the circuits that control gene expression. This has increased the urgency …

[HTML][HTML] A review of current concepts of the etiology and treatment of myopia

J Cooper, AV Tkatchenko - Eye & contact lens, 2018 - ncbi.nlm.nih.gov
Myopia occurs in more than 50% of the population in many industrialized countries and is
expected to increase; complications associated with axial elongation from myopia are the …

[HTML][HTML] IMI pathologic myopia

K Ohno-Matsui, PC Wu, K Yamashiro… - … & visual science, 2021 - iovs.arvojournals.org
Pathologic myopia is a major cause of visual impairment worldwide. Pathologic myopia is
distinctly different from high myopia. High myopia is a high degree of myopic refractive error …

Updates of pathologic myopia

K Ohno-Matsui, TYY Lai, CC Lai… - Progress in retinal and eye …, 2016 - Elsevier
Complications from pathologic myopia are a major cause of visual impairment and
blindness, especially in east Asia. The eyes with pathologic myopia may develop loss of the …

[HTML][HTML] Increasing prevalence of myopia in Europe and the impact of education

KM Williams, G Bertelsen, P Cumberland, C Wolfram… - Ophthalmology, 2015 - Elsevier
Purpose To investigate whether myopia is becoming more common across Europe and
explore whether increasing education levels, an important environmental risk factor for …