Microfluidic organ/body-on-a-chip devices at the convergence of biology and microengineering

AR Perestrelo, ACP Águas, A Rainer, G Forte - Sensors, 2015 - mdpi.com
Recent advances in biomedical technologies are mostly related to the convergence of
biology with microengineering. For instance, microfluidic devices are now commonly found …

High-throughput microfluidic systems accelerated by artificial intelligence for biomedical applications

J Zhou, J Dong, H Hou, L Huang, J Li - Lab on a Chip, 2024 - pubs.rsc.org
High-throughput microfluidic systems are widely used in biomedical fields for tasks like
disease detection, drug testing, and material discovery. Despite the great advances in …

Microinjection in biomedical applications: An effortless autonomous omnidirectional microinjection system

S Zhuang, D Lei, X Yu, M Tong, W Lin… - IEEE Industrial …, 2023 - ieeexplore.ieee.org
Thanks to the advancements in micro-and nanomechatronics techniques, the capability to
inject foreign materials into target locations inside biosamples has become increasingly …

Optical mapping of neuronal activity during seizures in zebrafish

L Turrini, C Fornetto, G Marchetto, MC Müllenbroich… - Scientific reports, 2017 - nature.com
Mapping neuronal activity during the onset and propagation of epileptic seizures can
provide a better understanding of the mechanisms underlying this pathology and improve …

Microfluidic based optical microscopes on chip

P Paiè, R Martínez Vázquez, R Osellame… - Cytometry Part …, 2018 - Wiley Online Library
Last decade's advancements in optofluidics allowed obtaining an ever increasing
integration of different functionalities in lab on chip devices to culture, analyze, and …

Fish-on-a-chip: microfluidics for zebrafish research

F Yang, C Gao, P Wang, GJ Zhang, Z Chen - Lab on a Chip, 2016 - pubs.rsc.org
High-efficiency zebrafish (embryo) handling platforms are crucially needed to facilitate the
deciphering of the increasingly expanding vertebrate–organism model values. However, the …

A novel long-term, multi-channel and non-invasive electrophysiology platform for zebrafish

SG Hong, P Lee, SC Baraban, LP Lee - Scientific reports, 2016 - nature.com
Zebrafish are a popular vertebrate model for human neurological disorders and drug
discovery. Although fecundity, breeding convenience, genetic homology and optical …

Recent lab‐on‐chip developments for novel drug discovery

N Khalid, I Kobayashi… - … Reviews: Systems Biology …, 2017 - Wiley Online Library
Microelectromechanical systems (MEMS) and micro total analysis systems (μTAS)
revolutionized the biochemical and electronic industries, and this miniaturization process …

An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish

SKH Sy, DCW Chan, RCH Chan, J Lyu, Z Li… - Nature …, 2023 - nature.com
Studying chemosensory processing desires precise chemical cue presentation, behavioral
response monitoring, and large-scale neuronal activity recording. Here we present Fish-on …

Microfluidic devices for embryonic and larval zebrafish studies

A Khalili, P Rezai - Briefings in functional genomics, 2019 - academic.oup.com
Zebrafish or Danio rerio is an established model organism for studying the genetic, neuronal
and behavioral bases of diseases and for toxicology and drug screening. The embryonic …