It is of great significance to develop consensus, easy-to-use and conceptually new methods
for guaranteeing food safety. CRISPR/Cas system is an emerging technology with excellent …

Veterinary pharmaceuticals have been recently recognized as newly emerging
environmental contaminants. Indeed, because of their uncontrolled or overused disposal …

FEN1 plays a crucial role in tumor progression and proliferation, and it has been considered
a prospective cancer biomarker and druggable target. However, its detection is …

One of the highly attractive research directions in the electrochemiluminescence (ECL) field
is how to regulate and improve ECL efficiency. Quantum dots (QDs) are highly promising …

Detection of multiple biomarkers for accurate diagnosis of disease is highly desirable but
remains challenging. Here, we developed a versatile diagnostic biosensor (SMARTLOCK) …

Cytokine storm (CS) is a risky immune overreaction accompanied by significant elevations of
pro-inflammatory cytokines including interferon-γ (IFN-γ), interleukin and tumor necrosis …

Recently, CRISPR/Cas associated biosensors have been shown to have great potential in
sensing applications due to their high sensitivity and high base resolution. However, the …

Acute myocardial infarction (AMI) represents the leading cause of cardiovascular death
worldwide, and it is thus pivotal to develop effective approaches for the timely detection of …

Cas14a may recognize and randomly cleave ssDNAs without protospacer adjacent motif
(PAM) sequence restriction to benefit nucleic acid sensing. However, the sensitivity of …

The combination of the CRISPR/Cas system and biosensing is of profound significance in
small molecule diagnostics. Herein, we report a cascade dual-enzyme transformation …