CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

The serum-and glucocorticoid-inducible kinase-1 (SGK1) is ubiquitously expressed and
under genomic control by cell stress (including cell shrinkage) and hormones (including …

ABSTRACT CLC genes are expressed in species from bacteria to human and encode Cl−-
channels or Cl−/H+-exchangers. CLC proteins assemble to dimers, with each monomer …

The ubiquitously expressed serum‐and glucocorticoid‐inducible kinase‐1 (SGK1) is
genomically regulated by cell stress (including cell shrinkage) and several hormones …

Abstract NEDD4-2 (also known as NEDD4L, neural precursor cell expressed
developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family …

The Nedd4 (neural precursor cell-expressed developmentally downregulated gene 4) family
of ubiquitin ligases (E3s) is characterized by a distinct modular domain architecture, with …

Regulation of renal Na+ transport is essential for controlling blood pressure, as well as Na+
and K+ homeostasis. Aldosterone stimulates Na+ reabsorption by the Na+-Cl− cotransporter …

Proteins of the CLC gene family assemble to homo-or sometimes heterodimers and either
function as Cl–channels or as Cl–/H+-exchangers. CLC proteins are present in all phyla …

Ubiquitylation of membrane proteins has gained considerable interest in recent years. It has
been recognized as a signal that negatively regulates the cell surface expression of many …

Target recognition by the ubiquitin system is mediated by E3 ubiquitin ligases. Nedd4 family
members are E3 ligases comprised of a C2 domain, 2–4 WW domains that bind PY motifs …