A novel approach to exploit Small-Molecule glucagon-like Peptide-1 receptor agonists with high potency
X Wang, Y Yun, L Chen, S Guo, B Niu, J Fang… - Bioorganic & Medicinal …, 2024 - Elsevier
Small-molecule glucagon-like peptide-1 receptor (GLP-1R) agonists are recognized as
promising therapeutics for type 2 diabetes mellitus (T2DM) and obesity. Danuglipron, an …
promising therapeutics for type 2 diabetes mellitus (T2DM) and obesity. Danuglipron, an …
Identification of highly selective type II kinase inhibitors with chiral peptidomimetic tails
SJ Han, JE Jung, DH Oh, M Kim, JM Kim… - Journal of Enzyme …, 2022 - Taylor & Francis
Identification of highly selective type II kinase inhibitors is described. Two different chiral
peptidomimetic scaffolds were introduced on the tail region of non-selective type II kinase …
peptidomimetic scaffolds were introduced on the tail region of non-selective type II kinase …
Recognition and release of uridine and hCNT3: From multivariate interactions to molecular design
H Duan, K Hu, D Zheng, Y Cheng, Z Zhang… - International Journal of …, 2022 - Elsevier
As a vital target for the development of novel anti-cancer drugs, human concentrative
nucleoside transporter 3 (hCNT3) has been widely concerned. Nevertheless, the lack of a …
nucleoside transporter 3 (hCNT3) has been widely concerned. Nevertheless, the lack of a …
Molecular basis of ligand binding and receptor activation at the human A3 adenosine receptor
L Zhang, JI Mobbs, FM Bennetts, H Venugopal… - bioRxiv, 2025 - biorxiv.org
Adenosine receptors (ARs: A1AR, A2AAR, A2BAR, and A3AR) are crucial therapeutic
targets, yet developing selective, efficacious drugs remains challenging. Here, we present …
targets, yet developing selective, efficacious drugs remains challenging. Here, we present …
水分子在药物设计中的作用
周洋， 陆小云 - 药学进展, 2022 - pps.cpu.edu.cn
水分子广泛存在于药物靶标蛋白中, 对于药物与靶标蛋白相互作用具有重要贡献. 在药物设计中,
替换水分子, 与水分子形成相互作用, 是优化化合物结构的有效方法. 近年来 …
替换水分子, 与水分子形成相互作用, 是优化化合物结构的有效方法. 近年来 …