IL-1β and the intestinal epithelial tight junction barrier

LW Kaminsky, R Al-Sadi, TY Ma - Frontiers in immunology, 2021 - frontiersin.org
The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of
contents from the intestinal lumen into the intestinal tissue and systemic circulation. A …

Evolving role of diet in the pathogenesis and treatment of inflammatory bowel diseases

A Levine, RS Boneh, E Wine - Gut, 2018 - gut.bmj.com
Recent advances in basic and clinical science over the last 3 years have dramatically
altered our appreciation of the role of diet in inflammatory bowel diseases (IBD). The marked …

Increased intestinal permeability is associated with later development of Crohn's disease

W Turpin, SH Lee, JAR Garay, KL Madsen… - Gastroenterology, 2020 - Elsevier
Background & Aims Increased intestinal permeability has been associated with Crohn's
disease (CD), but it is not clear whether it is a cause or result of the disease. We performed a …

Biomarkers for assessment of intestinal permeability in clinical practice

B Seethaler, M Basrai, AM Neyrinck… - American Journal …, 2021 - journals.physiology.org
Intestinal permeability is an important diagnostic marker, yet its determination by established
tests, which measure the urinary excretion of orally administered tracer molecules, is time …

Intestinal permeability in inflammatory bowel disease: pathogenesis, clinical evaluation, and therapy of leaky gut

A Michielan, R D'Incà - Mediators of inflammation, 2015 - Wiley Online Library
The pathogenesis of inflammatory bowel disease (IBD) is multifactorial with data suggesting
the role of a disturbed interaction between the gut and the intestinal microbiota. A defective …

The effectiveness of probiotics in the treatment of inflammatory bowel disease (IBD)—a critical review

D Jakubczyk, K Leszczyńska, S Górska - Nutrients, 2020 - mdpi.com
Inflammatory bowel disease (IBD), which affects millions of people worldwide, includes two
separate diseases: Crohn's disease (CD) and ulcerative colitis (UC). Although the …

Revisiting the gut–joint axis: links between gut inflammation and spondyloarthritis

E Gracey, L Vereecke, D McGovern… - Nature Reviews …, 2020 - nature.com
Gut inflammation is strongly associated with spondyloarthritis (SpA), as exemplified by the
high prevalence of inflammatory bowel disease (IBD) and the even higher occurrence of …

Diet as a trigger or therapy for inflammatory bowel diseases

JD Lewis, MT Abreu - Gastroenterology, 2017 - Elsevier
The most common question asked by patients with inflammatory bowel disease (IBD)
is,“Doctor, what should I eat?” Findings from epidemiology studies have indicated that diets …

The role of diet in the aetiopathogenesis of inflammatory bowel disease

H Khalili, SSM Chan, P Lochhead… - Nature Reviews …, 2018 - nature.com
Crohn's disease and ulcerative colitis, collectively known as IBD, are chronic inflammatory
disorders of the gastrointestinal tract. Although the aetiopathogenesis of IBD is largely …

Guts and gall: bile acids in regulation of intestinal epithelial function in health and disease

P Hegyi, J Maléth, JR Walters… - Physiological …, 2018 - journals.physiology.org
Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs
where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and …