Targeting the PDGF/PDGFR signaling pathway for cancer therapy: A review
X Zou, XY Tang, ZY Qu, ZW Sun, CF Ji, YJ Li… - International Journal of …, 2022 - Elsevier
Platelet-derived growth factors (PDGFs) and PDGF receptors (PDGFRs) are expressed in a
variety of tumors. Activation of the PDGF/PDGFR signaling pathway is associated with …
variety of tumors. Activation of the PDGF/PDGFR signaling pathway is associated with …
Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment
The nonreceptor protein tyrosine phosphatase SHP2 (encoded by PTPN11) integrates
growth and differentiation signals from receptor tyrosine kinases (RTKs) into the …
growth and differentiation signals from receptor tyrosine kinases (RTKs) into the …
RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1-and RAS-driven cancers
RJ Nichols, F Haderk, C Stahlhut, CJ Schulze… - Nature cell …, 2018 - nature.com
Oncogenic alterations in the RAS/RAF/MEK/ERK pathway drive the growth of a wide
spectrum of cancers. While BRAF and MEK inhibitors are efficacious against BRAFV600E …
spectrum of cancers. While BRAF and MEK inhibitors are efficacious against BRAFV600E …
High-throughput and high-sensitivity phosphoproteomics with the EasyPhos platform
Mass spectrometry has transformed the field of cell signaling by enabling global studies of
dynamic protein phosphorylation ('phosphoproteomics'). Recent developments are enabling …
dynamic protein phosphorylation ('phosphoproteomics'). Recent developments are enabling …
[HTML][HTML] Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ
Biological processes are regulated by intermolecular interactions and chemical
modifications that do not affect protein levels, thus escaping detection in classical proteomic …
modifications that do not affect protein levels, thus escaping detection in classical proteomic …
Allosteric SHP2 inhibitor, IACS-13909, overcomes EGFR-dependent and EGFR-independent resistance mechanisms toward osimertinib
Src homology 2 domain-containing phosphatase (SHP2) is a phosphatase that mediates
signaling downstream of multiple receptor tyrosine kinases (RTK) and is required for full …
signaling downstream of multiple receptor tyrosine kinases (RTK) and is required for full …
Multilayered control of protein turnover by TORC1 and Atg1
Z Hu, S Raucci, M Jaquenoud, R Hatakeyama… - Cell reports, 2019 - cell.com
The target of rapamycin complex 1 (TORC1) is a master regulator of cell homeostasis, which
promotes anabolic reactions and synchronously inhibits catabolic processes such as …
promotes anabolic reactions and synchronously inhibits catabolic processes such as …
Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth
Z Ye, G Kilic, S Dabelsteen, IN Marinova… - Science …, 2022 - science.org
Transforming growth factor–β (TGF-β) signaling regulates various aspects of cell growth and
differentiation and is often dysregulated in human cancers. We combined genetic …
differentiation and is often dysregulated in human cancers. We combined genetic …
The intrinsic substrate specificity of the human tyrosine kinome
Phosphorylation of proteins on tyrosine (Tyr) residues evolved in metazoan organisms as a
mechanism of coordinating tissue growth. Multicellular eukaryotes typically have more than …
mechanism of coordinating tissue growth. Multicellular eukaryotes typically have more than …
Optimization of fused bicyclic allosteric SHP2 inhibitors
JT Bagdanoff, Z Chen, M Acker, YN Chen… - Journal of medicinal …, 2019 - ACS Publications
SHP2 is a nonreceptor protein tyrosine phosphatase within the mitogen-activated protein
kinase (MAPK) pathway controlling cell growth, differentiation, and oncogenic …
kinase (MAPK) pathway controlling cell growth, differentiation, and oncogenic …